HCSGD entry for SHC2
1. General information
| Official gene symbol | SHC2 |
|---|---|
| Entrez ID | 25759 |
| Gene full name | SHC (Src homology 2 domain containing) transforming protein 2 |
| Other gene symbols | SCK SHCB SLI |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005575 | Cellular_component | ND | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0007265 | Ras protein signal transduction | TAS | biological_process |
| GO:0008286 | Insulin receptor signaling pathway | TAS | biological_process |
| GO:0035556 | Intracellular signal transduction | IEA | biological_process |
| GO:0048011 | Neurotrophin TRK receptor signaling pathway | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1196254132 | 0.7467194256 | 0.7083600675 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0600480640 |
| GSE13712_SHEAR | Down | -1.2371080203 |
| GSE13712_STATIC | Down | -0.5124896077 |
| GSE19018 | Down | -0.0416755832 |
| GSE19899_A1 | Up | 0.2166304524 |
| GSE19899_A2 | Up | 0.3520798092 |
| PubMed_21979375_A1 | Down | -0.4984885125 |
| PubMed_21979375_A2 | Up | 0.4757469795 |
| GSE35957 | Up | 0.2046391385 |
| GSE36640 | Up | 0.4252308517 |
| GSE54402 | Up | 0.2859391343 |
| GSE9593 | Up | 0.0206925088 |
| GSE43922 | Up | 0.1288570543 |
| GSE24585 | Up | 0.0085268810 |
| GSE37065 | Down | -0.0063515802 |
| GSE28863_A1 | Down | -0.1678823320 |
| GSE28863_A2 | Up | 0.5274896325 |
| GSE28863_A3 | Up | 0.3668666605 |
| GSE28863_A4 | Up | 0.0558686644 |
| GSE48662 | Up | 0.0866458206 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-186-5p | MIMAT0000456 | MIRT044976 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-26a-5p | MIMAT0000082 | MIRT050116 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
