HCSGD entry for SPDEF
1. General information
| Official gene symbol | SPDEF |
|---|---|
| Entrez ID | 25803 |
| Gene full name | SAM pointed domain containing ets transcription factor |
| Other gene symbols | PDEF RP11-375E1__A.3 bA375E1.3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0007275 | Multicellular organismal development | TAS | biological_process |
| GO:0010454 | Negative regulation of cell fate commitment | IEA | biological_process |
| GO:0010455 | Positive regulation of cell fate commitment | IEA | biological_process |
| GO:0043065 | Positive regulation of apoptotic process | IDA | biological_process |
| GO:0043565 | Sequence-specific DNA binding | IEA | molecular_function |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0060480 | Lung goblet cell differentiation | IEA | biological_process |
| GO:0060576 | Intestinal epithelial cell development | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7412580791 | 0.8232060902 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2200844878 |
| GSE13712_SHEAR | Down | -0.1021262672 |
| GSE13712_STATIC | Up | 0.1617894156 |
| GSE19018 | Down | -0.0319152171 |
| GSE19899_A1 | Down | -0.0398425547 |
| GSE19899_A2 | Up | 0.1488218266 |
| PubMed_21979375_A1 | Up | 0.1024243249 |
| PubMed_21979375_A2 | Down | -0.0581037853 |
| GSE35957 | Up | 0.1173444042 |
| GSE36640 | Up | 0.0610323908 |
| GSE54402 | Up | 0.0248050012 |
| GSE9593 | Up | 0.0137711664 |
| GSE43922 | Up | 0.0647954566 |
| GSE24585 | Up | 0.0084495781 |
| GSE37065 | Up | 0.0159640219 |
| GSE28863_A1 | Down | -0.0836731747 |
| GSE28863_A2 | Up | 0.0691038743 |
| GSE28863_A3 | Up | 0.1299218384 |
| GSE28863_A4 | Up | 0.0830945609 |
| GSE48662 | Up | 0.0710058145 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-204-5p | MIMAT0000265 | MIRT005337 | Luciferase reporter assay//Western blot | Functional MTI | 18922924 |
| hsa-miR-510-5p | MIMAT0002882 | MIRT005338 | Luciferase reporter assay//Western blot | Functional MTI | 18922924 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT018698 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-204-5p | MIMAT0000265 | NA | hsa-miR-204 | 18922924 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
