HCSGD entry for MTHFD1L
1. General information
| Official gene symbol | MTHFD1L |
|---|---|
| Entrez ID | 25902 |
| Gene full name | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like |
| Other gene symbols | FTHFSDC1 MTC1THFS dJ292B18.2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004329 | Formate-tetrahydrofolate ligase activity | IDA IEA | molecular_function |
| GO:0004477 | Methenyltetrahydrofolate cyclohydrolase activity | IBA | molecular_function |
| GO:0004488 | Methylenetetrahydrofolate dehydrogenase (NADP+) activity | IBA IEA | molecular_function |
| GO:0005524 | ATP binding | IDA IEA | molecular_function |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0005829 | Cytosol | IBA | cellular_component |
| GO:0006730 | One-carbon metabolic process | IBA | biological_process |
| GO:0006760 | Folic acid-containing compound metabolic process | IDA | biological_process |
| GO:0009396 | Folic acid-containing compound biosynthetic process | IEA | biological_process |
| GO:0015942 | Formate metabolic process | IDA | biological_process |
| GO:0035999 | Tetrahydrofolate interconversion | IEA | biological_process |
| GO:0042803 | Protein homodimerization activity | IDA | molecular_function |
| GO:0046653 | Tetrahydrofolate metabolic process | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9564677444 | 0.3966847764 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1553397073 |
| GSE13712_SHEAR | Up | 0.1738902893 |
| GSE13712_STATIC | Down | -0.0104646302 |
| GSE19018 | Up | 0.0551361043 |
| GSE19899_A1 | Up | 0.1702645040 |
| GSE19899_A2 | Down | -0.0461657943 |
| PubMed_21979375_A1 | Down | -0.0663256696 |
| PubMed_21979375_A2 | Down | -0.3003385163 |
| GSE35957 | Down | -0.0107232342 |
| GSE36640 | Down | -0.2860229663 |
| GSE54402 | Down | -0.0797211281 |
| GSE9593 | Down | -0.1199751557 |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Down | -0.1175804725 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-16-5p | MIMAT0000069 | MIRT031875 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-887-3p | MIMAT0004951 | MIRT036804 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040048 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT041690 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
