HCSGD entry for GART
1. General information
| Official gene symbol | GART |
|---|---|
| Entrez ID | 2618 |
| Gene full name | phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase |
| Other gene symbols | AIRS GARS GARTF PAIS PGFT PRGS |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003360 | Brainstem development | IEA | biological_process |
| GO:0003824 | Catalytic activity | IEA | molecular_function |
| GO:0004637 | Phosphoribosylamine-glycine ligase activity | IEA | molecular_function |
| GO:0004641 | Phosphoribosylformylglycinamidine cyclo-ligase activity | IEA | molecular_function |
| GO:0004644 | Phosphoribosylglycinamide formyltransferase activity | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006144 | Purine nucleobase metabolic process | TAS | biological_process |
| GO:0006189 | 'de novo' IMP biosynthetic process | IEA | biological_process |
| GO:0006544 | Glycine metabolic process | IEA | biological_process |
| GO:0008168 | Methyltransferase activity | IEA | molecular_function |
| GO:0009113 | Purine nucleobase biosynthetic process | IEA | biological_process |
| GO:0009156 | Ribonucleoside monophosphate biosynthetic process | IEA | biological_process |
| GO:0009168 | Purine ribonucleoside monophosphate biosynthetic process | TAS | biological_process |
| GO:0010033 | Response to organic substance | IEA | biological_process |
| GO:0010035 | Response to inorganic substance | IEA | biological_process |
| GO:0021549 | Cerebellum development | IEA | biological_process |
| GO:0021987 | Cerebral cortex development | IEA | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046654 | Tetrahydrofolate biosynthetic process | IEA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0055086 | Nucleobase-containing small molecule metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4322394058 | 0.4587201170 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1783987245 |
| GSE13712_SHEAR | Up | 0.4916115487 |
| GSE13712_STATIC | Up | 0.2167119977 |
| GSE19018 | Down | -0.0646392584 |
| GSE19899_A1 | Up | 0.1507801291 |
| GSE19899_A2 | Up | 0.1628163971 |
| PubMed_21979375_A1 | Up | 0.0557593842 |
| PubMed_21979375_A2 | Up | 0.0029966285 |
| GSE35957 | Down | -0.5612036157 |
| GSE36640 | Down | -0.7043356442 |
| GSE54402 | Up | 0.1313853778 |
| GSE9593 | Down | -0.2407023695 |
| GSE43922 | Up | 0.2864042986 |
| GSE24585 | Down | -0.2576589708 |
| GSE37065 | Down | -0.1782860117 |
| GSE28863_A1 | Up | 0.0748369944 |
| GSE28863_A2 | Up | 0.3031990745 |
| GSE28863_A3 | Down | -0.2711643996 |
| GSE28863_A4 | Up | 0.0553740452 |
| GSE48662 | Down | -0.3239632540 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Pemetrexed | DB00642 | APRD00573 | EXPT02075 |
| Glycinamide Ribonucleotide | DB02236 | EXPT01547 |
| 10-CF3C(OH)2-DDACTHF | DB03546 | EXPT01969 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-744-5p | MIMAT0004945 | MIRT037430 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-769-5p | MIMAT0003886 | MIRT039189 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039806 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-18a-3p | MIMAT0002891 | MIRT040950 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT042138 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-342-3p | MIMAT0000753 | MIRT043703 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044765 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 16539728 | We found strong over-expression of the purine biosynthesis gene GART (mean 3-fold) in fetal hearts with +21 and verified this result by northern blotting and real-time RT-PCR |
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