HCSGD entry for PDCD4
1. General information
| Official gene symbol | PDCD4 |
|---|---|
| Entrez ID | 27250 |
| Gene full name | programmed cell death 4 (neoplastic transformation inhibitor) |
| Other gene symbols | H731 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA IMP ISS | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IMP | cellular_component |
| GO:0005829 | Cytosol | IDA | cellular_component |
| GO:0006915 | Apoptotic process | NAS | biological_process |
| GO:0007569 | Cell aging | IDA | biological_process |
| GO:0043508 | Negative regulation of JUN kinase activity | ISS | biological_process |
| GO:0045786 | Negative regulation of cell cycle | NAS | biological_process |
| GO:0045892 | Negative regulation of transcription, DNA-templated | IDA ISS | biological_process |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5851098932 | 0.6997787242 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1216583042 |
| GSE13712_SHEAR | Down | -0.0835470224 |
| GSE13712_STATIC | Down | -0.1712521231 |
| GSE19018 | Down | -0.0756832186 |
| GSE19899_A1 | Up | 0.2739707145 |
| GSE19899_A2 | Up | 0.0478802684 |
| PubMed_21979375_A1 | Up | 0.1419506014 |
| PubMed_21979375_A2 | Down | -0.4326223690 |
| GSE35957 | Down | -0.0907506204 |
| GSE36640 | Up | 0.2598321620 |
| GSE54402 | Down | -0.1121984061 |
| GSE9593 | Down | -0.1305483306 |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Up | 0.3231996994 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-16-5p | MIMAT0000069 | MIRT000809 | qRT-PCR | Functional MTI (Weak) | 18362358 |
| hsa-miR-15a-5p | MIMAT0000068 | MIRT000810 | qRT-PCR | Functional MTI (Weak) | 18362358 |
| hsa-miR-1 | MIMAT0000416 | MIRT002785 | Microarray | Functional MTI (Weak) | 15685193 |
| hsa-miR-1 | MIMAT0000416 | MIRT002785 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT003054 | Luciferase reporter assay//Westren blot//Reporter assay | Functional MTI | 17968323 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT003054 | Western blot | Functional MTI | 19672202 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT003054 | Western blot | Functional MTI | 19509156 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT003054 | Luciferase reporter assay//Western blot | Functional MTI | 19682430 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT003054 | qRT-PCR//Western blot | Functional MTI | 19906824 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT003054 | Luciferase reporter assay//Western blot//Reporter assay;Other//Reporter assay | Functional MTI | 18270520 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT003054 | Western blot//Northern blot//qRT-PCR//Luciferase reporter assay | Functional MTI | 19013014 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT003054 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 18850008 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT003054 | qRT-PCR//Luciferase reporter assay//Western blot | Functional MTI | 20143188 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT003054 | Luciferase reporter assay | Functional MTI | 19836969 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT003054 | Luciferase reporter assay | Functional MTI | 19419954 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT003054 | Luciferase reporter assay//Reporter assay | Functional MTI | 18372920 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT003054 | Luciferase reporter assay | Functional MTI | 19133651 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT003054 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 19264808 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT003054 | Luciferase reporter assay | Functional MTI | 20056717 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT003054 | Immunohistochemistry//qRT-PCR//Western blot | Functional MTI | 20831814 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT003054 | GFP reporter assay//Northern blot//qRT-PCR//Western blot//ASO assay | Functional MTI | 19641183 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT003054 | Luciferase reporter assay//qRT-PCR//Quantitative proteomic approach | Functional MTI | 19253296 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT003054 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 19276261 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT003054 | Luciferase reporter assay//qRT-PCR | Functional MTI | 18829576 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT003054 | Immunoblot//Immunofluorescence//Luciferase reporter assay//qRT-PCR | Functional MTI | 20533548 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT003054 | Microarray//Northern blot | Functional MTI (Weak) | 16966691 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT003054 | Immunohistochemistry//qRT-PCR//Western blot | Functional MTI | 20978511 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT003054 | Luciferase reporter assay | Functional MTI | 21469086 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT003054 | Immunohistochemistry | Functional MTI (WeaK) | 19473551 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT003054 | Luciferase reporter assay//Western blot | Functional MTI | 20219857 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT003054 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT003054 | Microarray | Functional MTI (Weak) | 18591254 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT003054 | Reporter assay | Functional MTI | 17991735 |
| hsa-miR-200a-3p | MIMAT0000682 | MIRT004005 | Microarray | Functional MTI (Weak) | 17875710 |
| hsa-miR-183-5p | MIMAT0000261 | MIRT005547 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 20602797 |
| hsa-miR-499b-5p | MIMAT0019897 | MIRT006699 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 21934092 |
| hsa-miR-182-5p | MIMAT0000259 | MIRT007155 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 23296900 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT019086 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-196a-5p | MIMAT0000226 | MIRT026027 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-197-3p | MIMAT0000227 | MIRT048135 | CLASH | Functional MTI (Weak) | 23622248 |
Entries Per Page
Displaying Page of
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | NA | hsa-miR-1 | 15685193 | |||
| hsa-miR-21-5p | MIMAT0000076 | 1 | hsa-miR-21 | {Western blot} | {underexpression by 2'-O-Me antisense miRNA oligonucleotides} | 18372920 | |
| hsa-miR-21-5p | MIMAT0000076 | 1 | hsa-miR-21 | {Western blot} | {underexpression by 2'-O-Me antisense miRNA oligonucleotides} | 18270520 | |
| hsa-miR-21-5p | MIMAT0000076 | 1 | hsa-miR-21 | {Western blot}{Western blot} | {underexpression by anti-miRNA oligonucleotides}{overexpression by miRNA precursor transfection} | 17968323 | |
| hsa-miR-21-5p | MIMAT0000076 | 1 | hsa-miR-21 | {Western blot}{Western blot} | {underexpression by LNA antisense miRNA oligonucleotides}{overexpression by miRNA precursor transfection} | 17991735 | |
| hsa-miR-15a-5p | MIMAT0000068 | NA | hsa-miR-15a | 18362358 | |||
| hsa-miR-16-5p | MIMAT0000069 | NA | hsa-miR-16 | 18362358 | |||
| hsa-miR-1 | MIMAT0000416 | NA | hsa-miR-1 | 15685193 | |||
| hsa-miR-21-5p | MIMAT0000076 | 1 | hsa-miR-21 | 19013014 | |||
| hsa-miR-21-5p | MIMAT0000076 | 1 | hsa-miR-21 | {Western blot} | {downregulation by anti-miRNA oligonucleotide} | 19276261 | |
| hsa-miR-21-5p | MIMAT0000076 | NA | hsa-miR-21 | {Western blot} | {overexpression by miRNA precursor transfection} | 19906824 |
Entries Per Page
Displaying Page of
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26118837 | Here we investigate the gene expression of different target genes related to cell death, namely programmed cell death 4 (PDCD4), tumor susceptibility gene 101 (TSG101), developmental and cell death (DCD) domain, death specific protein (DSP) and metacaspase (MC), using RT-qPCR in the cosmopolitan coastal centric diatom species Skeletonema marinoi, which contributes significantly to phytoplankton blooms in temperate waters |
| 26118837 | On the contrary, PDCD4, DCD, TSG101 and MC did not show any significant variation |
Entries Per Page
Displaying Page of
