HCSGD entry for ABO

1. General information

Official gene symbolABO
Entrez ID28
Gene full nameABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
Other gene symbolsA3GALNT A3GALT1 GTB NAGAT
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004380Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activityIEAmolecular_function
GO:0004381Fucosylgalactoside 3-alpha-galactosyltransferase activityIEAmolecular_function
GO:0005576Extracellular regionIEAcellular_component
GO:0006486Protein glycosylationIEAbiological_process
GO:0016021Integral component of membraneIEAcellular_component
GO:0032580Golgi cisterna membraneIEAcellular_component
GO:0046872Metal ion bindingIEAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.24687756160.96336199230.93497387431.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0341171562
GSE13712_SHEARUp0.1905363512
GSE13712_STATICUp0.1177255106
GSE19018Up0.0256012374
GSE19899_A1Up0.1219151814
GSE19899_A2Up0.1434360856
PubMed_21979375_A1Down-0.1651012728
PubMed_21979375_A2Down-0.0069313451
GSE35957Up0.1652757317
GSE36640Up0.0640591580
GSE54402Up0.0506051704
GSE9593Up0.1988214127
GSE43922Up0.1471389004
GSE24585Up0.1433681445
GSE37065Down-0.0643917869
GSE28863_A1Up0.0260410616
GSE28863_A2Up0.0545924796
GSE28863_A3Up0.3652101732
GSE28863_A4Up0.0593562945
GSE48662Up0.0098150470

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Uridine-Diphosphate-N-AcetylgalactosamineDB02196 EXPT03169
Uridine-5'-DiphosphateDB03435 EXPT03172
2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,5-DiolDB03772 EXPT01217
2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-TriolDB04141 EXPT00697
H TYPE II TRISACCHARIDEDB04678 -
H TYPE I TRISACCHARIDEDB04679 -
GALACTOSE GREASEDB04680 -
BETA-METHYLLACTOSIDEDB04681 -
octyl 3-amino-3-deoxy-2-O-(2,6-dideoxy-alpha-L-lyxo-hexopyranosyl)-beta-D-galactopyranosideDB07341 -
4-AMINO-2-HEXYLOXY-6-HYDROXYMETHYL-TETRAHYDRO-PYRAN-3,5-DIOLDB07357 -
4-AMINO-2-OCTYLOXY-6-HYDROXYMETHYL-TETRAHYDRO-PYRAN-3,5-DIOLDB07378 -
octyl 3-deoxy-2-O-(6-deoxy-alpha-L-galactopyranosyl)-beta-D-xylo-hexopyranosideDB07633 -

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26677855The loci that replicated (FDR < 5%) included APOE/TOMM40 (associated with Alzheimer's disease), CDKN2B/ANRIL (implicated in the regulation of cellular senescence), ABO (tags the O blood group), and SH2B3/ATXN2 (a signaling gene that extends lifespan in Drosophila and a gene involved in neurological disease)
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