HCSGD entry for RAPGEF1

1. General information

Official gene symbolRAPGEF1
Entrez ID2889
Gene full nameRap guanine nucleotide exchange factor (GEF) 1
Other gene symbolsC3G GRF2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000186Activation of MAPKK activityTASbiological_process
GO:0001568Blood vessel developmentIEAbiological_process
GO:0005085Guanyl-nucleotide exchange factor activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005622IntracellularIEAcellular_component
GO:0005768EndosomeTAScellular_component
GO:0005769Early endosomeIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0007165Signal transductionNASbiological_process
GO:0007169Transmembrane receptor protein tyrosine kinase signaling pathwayTASbiological_process
GO:0007264Small GTPase mediated signal transductionIEAbiological_process
GO:0010976Positive regulation of neuron projection developmentIMPbiological_process
GO:0016337Cell-cell adhesionIEAbiological_process
GO:0017034Rap guanyl-nucleotide exchange factor activityIDA IMPmolecular_function
GO:0017124SH3 domain bindingIEAmolecular_function
GO:0032486Rap protein signal transductionIMPbiological_process
GO:0032854Positive regulation of Rap GTPase activityIDA IMPbiological_process
GO:0038180Nerve growth factor signaling pathwayIDAbiological_process
GO:0048008Platelet-derived growth factor receptor signaling pathwayIEAbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0051056Regulation of small GTPase mediated signal transductionIEAbiological_process
GO:0061028Establishment of endothelial barrierIMPbiological_process
GO:0071320Cellular response to cAMPIDAbiological_process
GO:1901888Regulation of cell junction assemblyIMPbiological_process
GO:1990090Cellular response to nerve growth factor stimulusIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.11837935110.68709604880.70590459901.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0942341981
GSE13712_SHEARDown-0.1028795837
GSE13712_STATICDown-0.1730208959
GSE19018Down-0.2031693737
GSE19899_A1Down-0.0818360192
GSE19899_A2Down-0.0549871538
PubMed_21979375_A1Up0.8049880608
PubMed_21979375_A2Up0.3500310936
GSE35957Up0.2165911833
GSE36640Up0.4187465166
GSE54402Up0.1265479921
GSE9593Up0.6093405397
GSE43922Down-0.0471652152
GSE24585Down-0.5538110975
GSE37065Down-0.0228805818
GSE28863_A1Up0.4059662303
GSE28863_A2Up0.0842570392
GSE28863_A3Up0.0546797409
GSE28863_A4Up0.0361804554
GSE48662Up0.4607739693

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-375MIMAT0000728MIRT019993MicroarrayFunctional MTI (Weak)20215506
hsa-miR-615-3pMIMAT0003283MIRT039719CLASHFunctional MTI (Weak)23622248
hsa-miR-193b-3pMIMAT0002819MIRT041498CLASHFunctional MTI (Weak)23622248
hsa-miR-339-5pMIMAT0000764MIRT042785CLASHFunctional MTI (Weak)23622248
hsa-miR-27b-3pMIMAT0000419MIRT046173CLASHFunctional MTI (Weak)23622248
hsa-miR-25-3pMIMAT0000081MIRT050309CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.