HCSGD entry for CXCL2
1. General information
| Official gene symbol | CXCL2 |
|---|---|
| Entrez ID | 2920 |
| Gene full name | chemokine (C-X-C motif) ligand 2 |
| Other gene symbols | CINC-2a GRO2 GROb MGSA-b MIP-2a MIP2 MIP2A SCYB2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002237 | Response to molecule of bacterial origin | IDA | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | TAS | cellular_component |
| GO:0005615 | Extracellular space | IEA | cellular_component |
| GO:0006935 | Chemotaxis | TAS | biological_process |
| GO:0006954 | Inflammatory response | IEA | biological_process |
| GO:0006955 | Immune response | IEA | biological_process |
| GO:0008009 | Chemokine activity | IEA | molecular_function |
| GO:0060326 | Cell chemotaxis | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0004566126 | 0.8899539569 | 0.0584791262 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 1.2204432030 |
| GSE13712_SHEAR | Down | -0.0451962194 |
| GSE13712_STATIC | Up | 0.0711080728 |
| GSE19018 | Down | -0.1282956124 |
| GSE19899_A1 | Up | 2.1761184687 |
| GSE19899_A2 | Up | 3.1316714684 |
| PubMed_21979375_A1 | Up | 3.6924409624 |
| PubMed_21979375_A2 | Up | 3.1121372791 |
| GSE35957 | Down | -0.1830246344 |
| GSE36640 | Down | -0.0666946407 |
| GSE54402 | Up | 1.8493899520 |
| GSE9593 | Down | -0.4598616941 |
| GSE43922 | Up | 1.0885526621 |
| GSE24585 | Up | 0.0978438340 |
| GSE37065 | Up | 1.2187867168 |
| GSE28863_A1 | Up | 0.2642012851 |
| GSE28863_A2 | Up | 0.0242339654 |
| GSE28863_A3 | Up | 0.1837754348 |
| GSE28863_A4 | Down | -0.2244275267 |
| GSE48662 | Down | -0.0630814868 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018317 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-1 | MIMAT0000416 | MIRT023893 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-98-5p | MIMAT0000096 | MIRT027726 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 21084274 | Many of these induced mRNA changes are in secreted proteins, IL-6, IL-8, and IL-11 and chemokines CXCL2 and CXCL5, or genes associated with an "inflammatory" phenotype |
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