HCSGD entry for GSK3A

1. General information

Official gene symbolGSK3A
Entrez ID2931
Gene full nameglycogen synthase kinase 3 alpha
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003073Regulation of systemic arterial blood pressureISSbiological_process
GO:0003214Cardiac left ventricle morphogenesisISSbiological_process
GO:0004674Protein serine/threonine kinase activityIDA IEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005829CytosolTAScellular_component
GO:0005977Glycogen metabolic processIEAbiological_process
GO:0006468Protein phosphorylationIDAbiological_process
GO:0006987Activation of signaling protein activity involved in unfolded protein responseTASbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007399Nervous system developmentIEAbiological_process
GO:0008286Insulin receptor signaling pathwayISSbiological_process
GO:0008543Fibroblast growth factor receptor signaling pathwayTASbiological_process
GO:0010905Negative regulation of UDP-glucose catabolic processICbiological_process
GO:0016055Wnt signaling pathwayIEAbiological_process
GO:0030819Positive regulation of cAMP biosynthetic processISSbiological_process
GO:0030877Beta-catenin destruction complexNAS TAScellular_component
GO:0030968Endoplasmic reticulum unfolded protein responseTASbiological_process
GO:0032007Negative regulation of TOR signalingISSbiological_process
GO:0032869Cellular response to insulin stimulusIMPbiological_process
GO:0034236Protein kinase A catalytic subunit bindingIPImolecular_function
GO:0036016Cellular response to interleukin-3ISSbiological_process
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0043161Proteasome-mediated ubiquitin-dependent protein catabolic processISSbiological_process
GO:0044267Cellular protein metabolic processTASbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045719Negative regulation of glycogen biosynthetic processTASbiological_process
GO:0045732Positive regulation of protein catabolic processNASbiological_process
GO:0045823Positive regulation of heart contractionISSbiological_process
GO:0046325Negative regulation of glucose importIMPbiological_process
GO:0046627Negative regulation of insulin receptor signaling pathwayIMPbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0048015Phosphatidylinositol-mediated signalingTASbiological_process
GO:0050321Tau-protein kinase activityTASmolecular_function
GO:0051348Negative regulation of transferase activityIMPbiological_process
GO:0061052Negative regulation of cell growth involved in cardiac muscle cell developmentISSbiological_process
GO:0071879Positive regulation of adrenergic receptor signaling pathwayISSbiological_process
GO:0090090Negative regulation of canonical Wnt signaling pathwayTASbiological_process
GO:0097192Extrinsic apoptotic signaling pathway in absence of ligandISSbiological_process
GO:1901030Positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathwayISSbiological_process
GO:2000077Negative regulation of type B pancreatic cell developmentTASbiological_process
GO:2000466Negative regulation of glycogen (starch) synthase activityTASbiological_process
GO:2000467Positive regulation of glycogen (starch) synthase activityISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.62948622390.56511722580.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0898241363
GSE13712_SHEARDown-0.0296473180
GSE13712_STATICDown-0.1547105714
GSE19018Up0.0677762234
GSE19899_A1Down-0.0284778289
GSE19899_A2Up0.1659736157
PubMed_21979375_A1Up0.0834556079
PubMed_21979375_A2Down-0.0930983107
GSE35957Up0.1385150485
GSE36640Down-0.0803848264
GSE54402Up0.2293121742
GSE9593Down-0.0723182543
GSE43922Up0.5824102033
GSE24585Down-0.1109897013
GSE37065Down-0.0232962681
GSE28863_A1Up0.0090149403
GSE28863_A2Down-0.1191001106
GSE28863_A3Down-0.3529156987
GSE28863_A4Down-0.0443923583
GSE48662Up0.1579234085

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-744-5pMIMAT0004945MIRT037683CLASHFunctional MTI (Weak)23622248
hsa-miR-149-5pMIMAT0000450MIRT045619CLASHFunctional MTI (Weak)23622248
hsa-let-7c-5pMIMAT0000064MIRT051796CLASHFunctional MTI (Weak)23622248
hsa-let-7b-5pMIMAT0000063MIRT052236CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24396695RESULTS: In this model of stress-induced cell senescence using DFO and H2O2, the phosphorylation profile of glycogen synthase kinase 3alpha (GSK3alpha) and beta corresponded closely to the expression profile of the mature form of SREBP-1 protein
24396695Suppression of GSK3 expression with siRNAs specific to GSK3alpha and beta also increased mature SREBP1 expression and induced senescence
22652454TGF beta1 progressively phosphorylated the negative regulatory sites of both glycogen synthase kinase 3 (GSK3) alpha and beta, corresponding well to the intracellular ROS generation profile
15379854Compared with young and middle-aged human WI-38 fibroblasts, senescent cells were found to contain increased nuclear levels of GSK3beta, and also tended to accumulate in the nucleus the other isoform of GSK3, GSK3alpha
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