HCSGD entry for GUK1
1. General information
| Official gene symbol | GUK1 |
|---|---|
| Entrez ID | 2987 |
| Gene full name | guanylate kinase 1 |
| Other gene symbols | GMK |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004385 | Guanylate kinase activity | IDA IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006163 | Purine nucleotide metabolic process | IDA IEA | biological_process |
| GO:0006185 | DGDP biosynthetic process | IEA | biological_process |
| GO:0015949 | Nucleobase-containing small molecule interconversion | TAS | biological_process |
| GO:0017144 | Drug metabolic process | TAS | biological_process |
| GO:0019673 | GDP-mannose metabolic process | IEA | biological_process |
| GO:0034436 | Glycoprotein transport | IEA | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046034 | ATP metabolic process | IEA | biological_process |
| GO:0046037 | GMP metabolic process | IEA | biological_process |
| GO:0046054 | DGMP metabolic process | IEA | biological_process |
| GO:0046060 | DATP metabolic process | IEA | biological_process |
| GO:0046711 | GDP biosynthetic process | IEA | biological_process |
| GO:0055086 | Nucleobase-containing small molecule metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3338254968 | 0.5966951332 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0166545078 |
| GSE13712_SHEAR | Down | -0.0283618510 |
| GSE13712_STATIC | Up | 0.0081025833 |
| GSE19018 | Up | 0.5894800620 |
| GSE19899_A1 | Down | -0.2478073602 |
| GSE19899_A2 | Up | 0.4850952295 |
| PubMed_21979375_A1 | Up | 0.6154111451 |
| PubMed_21979375_A2 | Up | 0.3091709387 |
| GSE35957 | Down | -0.0646269958 |
| GSE36640 | Up | 0.7072983434 |
| GSE54402 | Up | 0.1656039102 |
| GSE9593 | Up | 0.2092985652 |
| GSE43922 | Down | -0.0447988422 |
| GSE24585 | Down | -0.1073845399 |
| GSE37065 | Down | -0.1282417372 |
| GSE28863_A1 | Down | -0.1860953027 |
| GSE28863_A2 | Down | -0.1369293182 |
| GSE28863_A3 | Down | -0.2693395843 |
| GSE28863_A4 | Down | -0.0163674078 |
| GSE48662 | Down | -0.1488034023 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Guanosine-5'-Monophosphate | DB01972 | EXPT00246 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT022938 | Microarray | Functional MTI (Weak) | 18668037 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
