HCSGD entry for HDC

1. General information

Official gene symbolHDC
Entrez ID3067
Gene full namehistidine decarboxylase
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001694Histamine biosynthetic processIDA IEAbiological_process
GO:0004398Histidine decarboxylase activityIDA TASmolecular_function
GO:0005829CytosolTAScellular_component
GO:0006520Cellular amino acid metabolic processIEAbiological_process
GO:0006547Histidine metabolic processTASbiological_process
GO:0006548Histidine catabolic processIDA TASbiological_process
GO:0016831Carboxy-lyase activityIEAmolecular_function
GO:0030170Pyridoxal phosphate bindingIEAmolecular_function
GO:0034641Cellular nitrogen compound metabolic processTASbiological_process
GO:0042423Catecholamine biosynthetic processIEAbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.40719369700.90913101710.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1484649545
GSE13712_SHEARDown-0.0798396983
GSE13712_STATICUp0.0799686975
GSE19018Up0.3468941926
GSE19899_A1Up0.0355181562
GSE19899_A2Up0.2356781029
PubMed_21979375_A1Down-0.0126409859
PubMed_21979375_A2Down-0.0667111997
GSE35957Up0.0535325472
GSE36640Up0.0568032751
GSE54402Down-0.0219599654
GSE9593Up0.2176806799
GSE43922Up0.0171527094
GSE24585Up0.1028031357
GSE37065Down-0.0172789217
GSE28863_A1Up0.0289876454
GSE28863_A2Down-0.1123333839
GSE28863_A3Up0.1950698480
GSE28863_A4Up0.1726707361
GSE48662Up0.1743642953

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

16436134MC-specific genes, KIT and HDC were found in the tryptase cluster
6957863Senescent human diploid cells (HDC) were fused to replicative transformed cells of different types, and DNA synthesis was monitored in the resulting heterodikaryons
6957863Human cells transformed by simian virus 40 or adenovirus serotype 5 were able to induce DNA synthesis in senescent HDC nuclei in heterodikaryons
6957863In contrast, carcinogen-transformed cells were not able to induce DNA synthesis in senescent HDC nuclei; rather, the transformed nuclei in these heterodikaryons were inhibited from entering S phase
6957863Cells transformed by Rous sarcoma virus and most human tumor cells tested are similarly inhibited by fusion to senescent HDC
6957863A simple model to explain these results is that (i) senescent HDC contain an inhibitor of entry into S phase; (ii) cells transformed by DNA tumor viruses have gained a transforming factor, perhaps large tumor antigen, that is capable of overriding the normal inhibitor; and (iii) cells transformed by carcinogens or RNA viruses have lost or altered the mechanism for expression of the normal inhibitor yet are still sensitive to it
6957863The override of this inhibitor function in simian virus 40-transformed HDC can explain why they have low viability in plateau-phase cultures and why they die during crisis
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