HCSGD entry for HNRNPA2B1
1. General information
| Official gene symbol | HNRNPA2B1 |
|---|---|
| Entrez ID | 3181 |
| Gene full name | heterogeneous nuclear ribonucleoprotein A2/B1 |
| Other gene symbols | HNRNPA2 HNRNPB1 HNRPA2 HNRPA2B1 HNRPB1 RNPA2 SNRPB1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000166 | Nucleotide binding | IEA | molecular_function |
| GO:0000398 | MRNA splicing, via spliceosome | IC TAS | biological_process |
| GO:0003723 | RNA binding | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005681 | Spliceosomal complex | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006397 | MRNA processing | IDA | biological_process |
| GO:0008380 | RNA splicing | TAS | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0030529 | Ribonucleoprotein complex | IDA | cellular_component |
| GO:0043047 | Single-stranded telomeric DNA binding | IDA | molecular_function |
| GO:0048025 | Negative regulation of mRNA splicing, via spliceosome | IEA | biological_process |
| GO:0050658 | RNA transport | IDA | biological_process |
| GO:0071013 | Catalytic step 2 spliceosome | IDA | cellular_component |
| GO:0097157 | Pre-mRNA intronic binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9969131720 | 0.0080415296 | 0.9999902473 | 0.1786169620 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1418998090 |
| GSE13712_SHEAR | Down | -0.0144345930 |
| GSE13712_STATIC | Down | -0.3100409834 |
| GSE19018 | Down | -0.5802975747 |
| GSE19899_A1 | Down | -0.6741627562 |
| GSE19899_A2 | Down | -0.8422155680 |
| PubMed_21979375_A1 | Down | -0.6841772624 |
| PubMed_21979375_A2 | Down | -0.9228161605 |
| GSE35957 | Down | -0.5079592331 |
| GSE36640 | Down | -0.4333762425 |
| GSE54402 | Down | -0.1739444334 |
| GSE9593 | Down | -0.5576188218 |
| GSE43922 | Down | -0.5228048758 |
| GSE24585 | Up | 0.0901300863 |
| GSE37065 | Up | 0.0427228376 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Up | 0.0860522824 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-103a-3p | MIMAT0000101 | MIRT027027 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031508 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031508 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-1296-5p | MIMAT0005794 | MIRT036075 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-877-3p | MIMAT0004950 | MIRT037116 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040278 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-191-5p | MIMAT0000440 | MIRT045809 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-27b-3p | MIMAT0000419 | MIRT046213 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-30c-5p | MIMAT0000244 | MIRT048009 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-197-3p | MIMAT0000227 | MIRT048098 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049721 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7f-5p | MIMAT0000067 | MIRT051404 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-1260b | MIMAT0015041 | MIRT052680 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27363602 | Two splicing regulators, HNRNPA1 and HNRNPA2B1, were also associated with parental longevity in humans, in the InCHIANTI aging study |
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