HCSGD entry for HOXA9
1. General information
| Official gene symbol | HOXA9 |
|---|---|
| Entrez ID | 3205 |
| Gene full name | homeobox A9 |
| Other gene symbols | ABD-B HOX1 HOX1.7 HOX1G |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0005667 | Transcription factor complex | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0007275 | Multicellular organismal development | TAS | biological_process |
| GO:0009952 | Anterior/posterior pattern specification | IEA | biological_process |
| GO:0009954 | Proximal/distal pattern formation | IEA | biological_process |
| GO:0019899 | Enzyme binding | IPI | molecular_function |
| GO:0030879 | Mammary gland development | IEA | biological_process |
| GO:0035115 | Embryonic forelimb morphogenesis | IEA | biological_process |
| GO:0042118 | Endothelial cell activation | IMP | biological_process |
| GO:0043565 | Sequence-specific DNA binding | IEA | molecular_function |
| GO:0045638 | Negative regulation of myeloid cell differentiation | ISS | biological_process |
| GO:0048706 | Embryonic skeletal system development | IEA | biological_process |
| GO:0060216 | Definitive hemopoiesis | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3819255271 | 0.9741947380 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | - | - |
| GSE13712_SHEAR | - | - |
| GSE13712_STATIC | - | - |
| GSE19018 | - | - |
| GSE19899_A1 | - | - |
| GSE19899_A2 | - | - |
| PubMed_21979375_A1 | - | - |
| PubMed_21979375_A2 | - | - |
| GSE35957 | - | - |
| GSE36640 | - | - |
| GSE54402 | - | - |
| GSE9593 | - | - |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | Up | 0.0729414064 |
| GSE28863_A2 | Up | 0.2193624975 |
| GSE28863_A3 | Down | -0.2406099800 |
| GSE28863_A4 | Down | -0.0942483334 |
| GSE48662 | Up | 0.5805366937 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-210-3p | MIMAT0000267 | MIRT000149 | Luciferase reporter assay | Functional MTI | 19782034 |
| hsa-miR-145-5p | MIMAT0000437 | MIRT001917 | GFP reporter assay//qRT-PCR//Western blot | Non-Functional MTI | 18474618 |
| hsa-miR-126-3p | MIMAT0000445 | MIRT001918 | GFP reporter assay//qRT-PCR//Western blot//Luciferase reporter assay | Functional MTI | 18474618 |
| hsa-miR-652-3p | MIMAT0003322 | MIRT016142 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-340-5p | MIMAT0004692 | MIRT019591 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-101-3p | MIMAT0000099 | MIRT027337 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-96-5p | MIMAT0000095 | MIRT027927 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-33a-5p | MIMAT0000091 | MIRT028225 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT030092 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT030986 | Microarray | Functional MTI (Weak) | 18591254 |
| hsa-miR-18a-5p | MIMAT0000072 | MIRT031333 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-769-3p | MIMAT0003887 | MIRT039078 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-5p | MIMAT0000761 | MIRT043225 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24067365 | We showed that HLX1 and HOXA9 recruit PRCs to repress INK4a, which constitutes a key mechanism explaining their effects on senescence |
| 24067365 | Here we provide evidence for the regulation of additional senescence-associated PRC target genes by HLX1 and HOXA9 |
| 24067365 | As both HLX1 and HOXA9 are oncogenes implicated in leukemogenesis, we discuss the implications that the collaboration between Homeobox proteins and PRCs has for senescence and cancer |
| 21624810 | As reported for Bmi1, Hoxa9 regulates expression of p16(Ink4a)/p19(ARF) locus and could overcome senescence induced by AML1-ETO |
| 21310926 | Conversely, depletion of Kdm2b/Jhdm1b in hematopoietic progenitors significantly impairs Hoxa9/Meis1-induced leukemic transformation |
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