HCSGD entry for APBB1

1. General information

Official gene symbolAPBB1
Entrez ID322
Gene full nameamyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
Other gene symbolsFE65 MGC:9072 RIR
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001540Beta-amyloid bindingIPI NASmolecular_function
GO:0001764Neuron migrationIEAbiological_process
GO:0003682Chromatin bindingIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA ISScellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0006302Double-strand break repairIEAbiological_process
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006355Regulation of transcription, DNA-templatedISSbiological_process
GO:0006915Apoptotic processIEAbiological_process
GO:0006974Cellular response to DNA damage stimulusIDAbiological_process
GO:0007050Cell cycle arrestISSbiological_process
GO:0007165Signal transductionNASbiological_process
GO:0007409AxonogenesisNASbiological_process
GO:0007411Axon guidanceIEAbiological_process
GO:0008134Transcription factor bindingISSmolecular_function
GO:0008542Visual learningIEAbiological_process
GO:0016607Nuclear speckIEAcellular_component
GO:0030027LamellipodiumIDAcellular_component
GO:0030198Extracellular matrix organizationIEAbiological_process
GO:0030308Negative regulation of cell growthISSbiological_process
GO:0030426Growth coneIDAcellular_component
GO:0042393Histone bindingIPImolecular_function
GO:0043065Positive regulation of apoptotic processIDAbiological_process
GO:0043967Histone H4 acetylationISSbiological_process
GO:0045202SynapseIDAcellular_component
GO:0045665Negative regulation of neuron differentiationIEAbiological_process
GO:0045739Positive regulation of DNA repairIEAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0050760Negative regulation of thymidylate synthase biosynthetic processISSbiological_process
GO:0070064Proline-rich region bindingIPImolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.48163488090.23705175720.99999024730.9368130461

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.3381364278
GSE13712_SHEARDown-0.4887187633
GSE13712_STATICDown-0.1109162796
GSE19018Up0.2392517317
GSE19899_A1Down-0.3782077804
GSE19899_A2Down-0.1472440198
PubMed_21979375_A1Up0.1989723161
PubMed_21979375_A2Up0.1277701262
GSE35957Up0.1052993883
GSE36640Up0.2076569625
GSE54402Down-0.0600392368
GSE9593Up0.5184659706
GSE43922Down-0.0194579658
GSE24585Up0.3151325851
GSE37065Down-0.1694252332
GSE28863_A1Up0.2150388788
GSE28863_A2Down-0.1273507433
GSE28863_A3Down-0.1199859227
GSE28863_A4Down-0.1294949179
GSE48662Up0.2412549305

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT017493MicroarrayFunctional MTI (Weak)18185580
hsa-miR-148b-3pMIMAT0000759MIRT019356MicroarrayFunctional MTI (Weak)17612493
hsa-miR-331-3pMIMAT0000760MIRT043469CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.