HCSGD entry for HRG

1. General information

Official gene symbolHRG
Entrez ID3273
Gene full namehistidine-rich glycoprotein
Other gene symbolsHPRG HRGP THPH11
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001525AngiogenesisIEAbiological_process
GO:0002576Platelet degranulationTASbiological_process
GO:0002839Positive regulation of immune response to tumor cellIDAbiological_process
GO:0004867Serine-type endopeptidase inhibitor activityIEAmolecular_function
GO:0004869Cysteine-type endopeptidase inhibitor activityIEAmolecular_function
GO:0005102Receptor bindingIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionIDA NAS TAScellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0006935ChemotaxisIEAbiological_process
GO:0007162Negative regulation of cell adhesionIDAbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008201Heparin bindingIDAmolecular_function
GO:0008270Zinc ion bindingIDAmolecular_function
GO:0008285Negative regulation of cell proliferationIDAbiological_process
GO:0010468Regulation of gene expressionIDAbiological_process
GO:0010543Regulation of platelet activationISSbiological_process
GO:0010593Negative regulation of lamellipodium assemblyIDAbiological_process
GO:0016525Negative regulation of angiogenesisIDAbiological_process
GO:0019865Immunoglobulin bindingIDAmolecular_function
GO:0020037Heme bindingIDAmolecular_function
GO:0030168Platelet activationIDA TASbiological_process
GO:0030193Regulation of blood coagulationIDAbiological_process
GO:0030308Negative regulation of cell growthIDAbiological_process
GO:0031093Platelet alpha granule lumenTAScellular_component
GO:0032956Regulation of actin cytoskeleton organizationIDAbiological_process
GO:0033629Negative regulation of cell adhesion mediated by integrinIDAbiological_process
GO:0042730FibrinolysisTASbiological_process
GO:0043065Positive regulation of apoptotic processIDAbiological_process
GO:0043254Regulation of protein complex assemblyIDAbiological_process
GO:0043395Heparan sulfate proteoglycan bindingIDAmolecular_function
GO:0043537Negative regulation of blood vessel endothelial cell migrationISSbiological_process
GO:0046872Metal ion bindingIDAmolecular_function
GO:0050730Regulation of peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0050832Defense response to fungusIDAbiological_process
GO:0051894Positive regulation of focal adhesion assemblyIDAbiological_process
GO:0051918Negative regulation of fibrinolysisIEAbiological_process
GO:1900747Negative regulation of vascular endothelial growth factor signaling pathwayIDAbiological_process
GO:2000504Positive regulation of blood vessel remodelingIDAbiological_process
GO:2001027Negative regulation of endothelial cell chemotaxisIDAbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.67314235400.88652574750.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0113279328
GSE13712_SHEARUp0.0198032950
GSE13712_STATICDown-0.1396317080
GSE19018Up0.1189417727
GSE19899_A1Up0.0637884866
GSE19899_A2Up0.0874740644
PubMed_21979375_A1Up0.1064116273
PubMed_21979375_A2Up0.1048208864
GSE35957Up0.0762894270
GSE36640Up0.0080982448
GSE54402Up0.0072876144
GSE9593Down-0.0652120755
GSE43922Up0.0220653108
GSE24585Up0.2430630395
GSE37065Down-0.0264721455
GSE28863_A1Up0.0703496407
GSE28863_A2Up0.1125501283
GSE28863_A3Down-0.0307869853
GSE28863_A4Up0.0018668317
GSE48662Down-0.0303886139

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

22958206Greater tolerance to hypoxia in older progenitor cells, as evidenced by elevated HIF-1 promoter reporter activity and hypoxia response gene (HRG) expression, mirrors the upregulation of HRGs in cohorts of older vs
Entries Per Page
Displaying Page of