HCSGD entry for HSF4

1. General information

Official gene symbolHSF4
Entrez ID3299
Gene full nameheat shock transcription factor 4
Other gene symbolsCTM CTRCT5
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0003700Sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0003714Transcription corepressor activityTASmolecular_function
GO:0005634NucleusIEAcellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006355Regulation of transcription, DNA-templatedTASbiological_process
GO:0006357Regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0006950Response to stressIEAbiological_process
GO:0008284Positive regulation of cell proliferationIEAbiological_process
GO:0033169Histone H3-K9 demethylationIEAbiological_process
GO:0043010Camera-type eye developmentIEAbiological_process
GO:0043565Sequence-specific DNA bindingIEAmolecular_function
GO:0045597Positive regulation of cell differentiationIEAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0048468Cell developmentIEAbiological_process
GO:0070207Protein homotrimerizationIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.58264193230.68118517530.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1358870333
GSE13712_SHEARDown-0.0977876755
GSE13712_STATICDown-0.0484059439
GSE19018Down-0.0792547619
GSE19899_A1Down-0.0453316529
GSE19899_A2Up0.1826800229
PubMed_21979375_A1Up0.1856675299
PubMed_21979375_A2Down-0.1368717557
GSE35957Up0.0224506970
GSE36640Up0.0854031967
GSE54402Down-0.0620222353
GSE9593Up0.2116952286
GSE43922Up0.1440941071
GSE24585Down-0.1792661866
GSE37065Up0.0627827469
GSE28863_A1Down-0.2774375858
GSE28863_A2Up0.0330493624
GSE28863_A3Up0.3039199527
GSE28863_A4Up0.0221893478
GSE48662Up0.5508345766

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT029359MicroarrayFunctional MTI (Weak)19088304
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

23949429Interestingly, the polycomb repressive complex -2 (PCRC2) target genes Kiss1r, Nav2 and Hsf4 were hypermethylated with age
22355043Studies suggest that Hsf4 expression correlates with its role in cell growth and differentiation
22355043However, the role of Hsf4 in tumorigenesis in vivo remains unexplored
22355043In this article, we provide evidence that absence of the Hsf4 gene suppresses evolution of spontaneous tumors arising in p53- or Arf-deficient mice
22355043Our results therefore indicate that Hsf4 is involved in modulation of cellular senescence, which can be exploited during cancer therapy
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