HCSGD entry for BIRC3

1. General information

Official gene symbolBIRC3
Entrez ID330
Gene full namebaculoviral IAP repeat containing 3
Other gene symbolsAIP1 API2 CIAP2 HAIP1 HIAP1 MALT2 MIHC RNF49 c-IAP2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0002756MyD88-independent toll-like receptor signaling pathwayTASbiological_process
GO:0004842Ubiquitin-protein ligase activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006915Apoptotic processIEAbiological_process
GO:0007166Cell surface receptor signaling pathwayTASbiological_process
GO:0007283SpermatogenesisIEAbiological_process
GO:0008152Metabolic processIDAbiological_process
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0016567Protein ubiquitinationIDAbiological_process
GO:0031398Positive regulation of protein ubiquitinationIDAbiological_process
GO:0034121Regulation of toll-like receptor signaling pathwayTASbiological_process
GO:0034138Toll-like receptor 3 signaling pathwayTASbiological_process
GO:0034142Toll-like receptor 4 signaling pathwayTASbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0038061NIK/NF-kappaB signalingTASbiological_process
GO:0039535Regulation of RIG-I signaling pathwayTASbiological_process
GO:0042326Negative regulation of phosphorylationIEAbiological_process
GO:0042981Regulation of apoptotic processIMPbiological_process
GO:0043066Negative regulation of apoptotic processTASbiological_process
GO:0043123Positive regulation of I-kappaB kinase/NF-kappaB signalingTASbiological_process
GO:0043234Protein complexIEAcellular_component
GO:0045087Innate immune responseTASbiological_process
GO:0045088Regulation of innate immune responseTASbiological_process
GO:0045121Membrane raftIEAcellular_component
GO:0050727Regulation of inflammatory responseTASbiological_process
GO:0051291Protein heterooligomerizationIEAbiological_process
GO:0060544Regulation of necroptotic processIMPbiological_process
GO:0060546Negative regulation of necroptotic processIEAbiological_process
GO:0070266Necroptotic processIEAbiological_process
GO:0070424Regulation of nucleotide-binding oligomerization domain containing signaling pathwayTASbiological_process
GO:2000116Regulation of cysteine-type endopeptidase activityTASbiological_process
GO:2000378Negative regulation of reactive oxygen species metabolic processIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00161810340.82347136890.10796936711.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.2003285096
GSE13712_SHEARUp1.1553479265
GSE13712_STATICUp0.5168061929
GSE19018Down-0.3649048256
GSE19899_A1Up0.4695426335
GSE19899_A2Up1.1023427755
PubMed_21979375_A1Up0.8137717498
PubMed_21979375_A2Down-0.4068351148
GSE35957Up0.0019178121
GSE36640Down-1.0260069065
GSE54402Up1.5562226245
GSE9593Up0.5765742217
GSE43922Up0.8149944507
GSE24585Down-0.0595996382
GSE37065Up1.4563991321
GSE28863_A1Down-0.0866319939
GSE28863_A2Up0.5317835738
GSE28863_A3Up0.7052670863
GSE28863_A4Up0.0891287453
GSE48662Down-0.1170644540

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-34a-5pMIMAT0000255MIRT000071Microarray//Northern blotFunctional MTI (Weak)17540599
hsa-miR-375MIMAT0000728MIRT019771MicroarrayFunctional MTI (Weak)20215506
hsa-miR-98-5pMIMAT0000096MIRT027437MicroarrayFunctional MTI (Weak)19088304
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.