HCSGD entry for XIAP
1. General information
| Official gene symbol | XIAP |
|---|---|
| Entrez ID | 331 |
| Gene full name | X-linked inhibitor of apoptosis |
| Other gene symbols | API3 BIRC4 IAP-3 ILP1 MIHA XLP2 hIAP-3 hIAP3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004842 | Ubiquitin-protein ligase activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006915 | Apoptotic process | TAS | biological_process |
| GO:0006974 | Cellular response to DNA damage stimulus | IEP | biological_process |
| GO:0008152 | Metabolic process | IDA | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0016055 | Wnt signaling pathway | IEA | biological_process |
| GO:0016567 | Protein ubiquitination | IDA | biological_process |
| GO:0030510 | Regulation of BMP signaling pathway | TAS | biological_process |
| GO:0031398 | Positive regulation of protein ubiquitination | IDA | biological_process |
| GO:0042127 | Regulation of cell proliferation | TAS | biological_process |
| GO:0043027 | Cysteine-type endopeptidase inhibitor activity involved in apoptotic process | IDA | molecular_function |
| GO:0043066 | Negative regulation of apoptotic process | IMP | biological_process |
| GO:0043154 | Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | IDA | biological_process |
| GO:0045088 | Regulation of innate immune response | TAS | biological_process |
| GO:0050727 | Regulation of inflammatory response | TAS | biological_process |
| GO:0055070 | Copper ion homeostasis | TAS | biological_process |
| GO:0070424 | Regulation of nucleotide-binding oligomerization domain containing signaling pathway | TAS | biological_process |
| GO:0090263 | Positive regulation of canonical Wnt signaling pathway | IMP | biological_process |
| GO:0097193 | Intrinsic apoptotic signaling pathway | TAS | biological_process |
| GO:1902530 | Positive regulation of protein linear polyubiquitination | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0246603283 | 0.9889297633 | 0.3702706788 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.4714475717 |
| GSE13712_SHEAR | Up | 0.2456852381 |
| GSE13712_STATIC | Up | 0.1437452654 |
| GSE19018 | Down | -0.1078384804 |
| GSE19899_A1 | Up | 0.2488269463 |
| GSE19899_A2 | Up | 0.3469399530 |
| PubMed_21979375_A1 | Up | 0.3372251797 |
| PubMed_21979375_A2 | Up | 0.3421851283 |
| GSE35957 | Up | 0.2127121801 |
| GSE36640 | Up | 0.4228870189 |
| GSE54402 | Up | 0.4710057243 |
| GSE9593 | Up | 0.4989925879 |
| GSE43922 | Up | 0.2883782057 |
| GSE24585 | Up | 0.1822725126 |
| GSE37065 | Up | 0.0354425121 |
| GSE28863_A1 | Down | -0.0937094990 |
| GSE28863_A2 | Up | 0.0347606878 |
| GSE28863_A3 | Down | -0.4055732469 |
| GSE28863_A4 | Up | 0.1956264268 |
| GSE48662 | Up | 0.3679418195 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| 1-[3,3-Dimethyl-2-(2-Methylamino-Propionylamino)-Butyryl]-Pyrrolidine-2-Carboxylic Acid(1,2,3,4-Tetrahydro-Naphthalen-1-Yl)-Amide | DB02628 | EXPT00351 |
| N-METHYLALANYL-3-METHYLVALYL-4-PHENOXY-N-(1,2,3,4-TETRAHYDRONAPHTHALEN-1-YL)PROLINAMIDE | DB04612 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-34a-3p | MIMAT0004557 | MIRT006260 | Luciferase reporter assay | Functional MTI | 22161761 |
| hsa-miR-200b-3p | MIMAT0000318 | MIRT006671 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 21993663 |
| hsa-miR-200c-3p | MIMAT0000617 | MIRT006672 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 21993663 |
| hsa-miR-429 | MIMAT0001536 | MIRT006675 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 21993663 |
| hsa-miR-181a-5p | MIMAT0000256 | MIRT006950 | Luciferase reporter assay | Functional MTI | 22610076 |
| hsa-miR-181b-5p | MIMAT0000257 | MIRT006951 | Luciferase reporter assay | Functional MTI | 22610076 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024546 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026131 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-101-3p | MIMAT0000099 | MIRT027269 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-96-5p | MIMAT0000095 | MIRT027901 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-125b-5p | MIMAT0000423 | MIRT045901 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-106a-5p | MIMAT0000103 | MIRT048312 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-17-5p | MIMAT0000070 | MIRT050938 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7e-5p | MIMAT0000066 | MIRT051500 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26802028 | X-linked inhibitor of apoptosis (XIAP)-associated factor 1 (XAF1) is well known as an antagonist of XIAP-mediated caspase inhibition |
| 26152738 | In addition, senescent tumor cells had a lower apoptotic threshold due to decreased XIAP and survivin expression |
| 23936028 | Survivin deletion was also associated with reduced tumor expression of another inhibitor of apoptosis member, the X-linked inhibitor of apoptosis |
| 16600555 | Moreover, senescent cells induced activation of caspase-3/7 in epithelial cells, which was associated with down-regulation of the caspase-inhibitory protein XIAP |
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