HCSGD entry for HTR6
1. General information
| Official gene symbol | HTR6 |
|---|---|
| Entrez ID | 3362 |
| Gene full name | 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled |
| Other gene symbols | 5-HT6 5-HT6R |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004969 | Histamine receptor activity | TAS | molecular_function |
| GO:0004993 | Serotonin receptor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | TAS | cellular_component |
| GO:0005929 | Cilium | IEA | cellular_component |
| GO:0007187 | G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | IEA | biological_process |
| GO:0007268 | Synaptic transmission | TAS | biological_process |
| GO:0007420 | Brain development | IEA | biological_process |
| GO:0007612 | Learning | IEA | biological_process |
| GO:0014050 | Negative regulation of glutamate secretion | IEA | biological_process |
| GO:0014053 | Negative regulation of gamma-aminobutyric acid secretion | IEA | biological_process |
| GO:0014054 | Positive regulation of gamma-aminobutyric acid secretion | IEA | biological_process |
| GO:0014058 | Negative regulation of acetylcholine secretion, neurotransmission | IEA | biological_process |
| GO:0030425 | Dendrite | IEA | cellular_component |
| GO:0032355 | Response to estradiol | IEA | biological_process |
| GO:0033603 | Positive regulation of dopamine secretion | IEA | biological_process |
| GO:0042493 | Response to drug | IEA | biological_process |
| GO:0060291 | Long-term synaptic potentiation | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2880771551 | 0.9218306637 | 0.9867843091 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0059424918 |
| GSE13712_SHEAR | Up | 0.0033663434 |
| GSE13712_STATIC | Up | 0.0330328549 |
| GSE19018 | Up | 0.0066299310 |
| GSE19899_A1 | Up | 0.0957976290 |
| GSE19899_A2 | Up | 0.3123289924 |
| PubMed_21979375_A1 | Down | -0.0675195281 |
| PubMed_21979375_A2 | Up | 0.0093039140 |
| GSE35957 | Up | 0.0848325841 |
| GSE36640 | Up | 0.1292785883 |
| GSE54402 | Up | 0.1039550380 |
| GSE9593 | Up | 0.0272985269 |
| GSE43922 | Up | 0.1020649877 |
| GSE24585 | Down | -0.2426460318 |
| GSE37065 | Down | -0.0950272720 |
| GSE28863_A1 | Down | -0.1127476497 |
| GSE28863_A2 | Up | 0.1879361683 |
| GSE28863_A3 | Up | 0.1742525306 |
| GSE28863_A4 | Up | 0.4346115110 |
| GSE48662 | Up | 0.1547296179 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Ziprasidone | DB00246 | APRD00540 |
| Olanzapine | DB00334 | APRD00138 |
| Clozapine | DB00363 | APRD00470 |
| Loxapine | DB00408 | APRD00574 |
| Amoxapine | DB00543 | APRD00142 |
| Doxepin | DB01142 | APRD00398 |
| Quetiapine | DB01224 | APRD00675 |
| Aripiprazole | DB01238 | APRD00638 |
| Dimethyltryptamine | DB01488 | - |
| Iloperidone | DB04946 | - |
| SGS518 | DB05042 | - |
| Sertindole | DB06144 | - |
| Mianserin | DB06148 | - |
| Asenapine | DB06216 | - |
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
