HCSGD entry for TNC

1. General information

Official gene symbolTNC
Entrez ID3371
Gene full nametenascin C
Other gene symbols150-225 GMEM GP HXB JI TN TN-C
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005576Extracellular regionTAScellular_component
GO:0005604Basement membraneIEAcellular_component
GO:0005614Interstitial matrixIEAcellular_component
GO:0005615Extracellular spaceIDAcellular_component
GO:0007155Cell adhesionIEAbiological_process
GO:0007162Negative regulation of cell adhesionIEAbiological_process
GO:0007528Neuromuscular junction developmentIEAbiological_process
GO:0008284Positive regulation of cell proliferationIEAbiological_process
GO:0009611Response to woundingIEPbiological_process
GO:0009612Response to mechanical stimulusIEAbiological_process
GO:0010628Positive regulation of gene expressionIEAbiological_process
GO:0014012Peripheral nervous system axon regenerationIEAbiological_process
GO:0030198Extracellular matrix organizationTASbiological_process
GO:0031012Extracellular matrixIDA ISScellular_component
GO:0042060Wound healingIEAbiological_process
GO:0042475Odontogenesis of dentin-containing toothIEAbiological_process
GO:0045471Response to ethanolIEAbiological_process
GO:0045545Syndecan bindingIPImolecular_function
GO:0060447Bud outgrowth involved in lung branchingIEAbiological_process
GO:0060739Mesenchymal-epithelial cell signaling involved in prostate gland developmentIEAbiological_process
GO:0060740Prostate gland epithelium morphogenesisIEAbiological_process
GO:0071300Cellular response to retinoic acidIEAbiological_process
GO:0071305Cellular response to vitamin DIEAbiological_process
GO:0071774Response to fibroblast growth factorIEAbiological_process
GO:0071799Cellular response to prostaglandin D stimulusIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00490788720.01358349230.18365582390.2297854756

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.4247059411
GSE13712_SHEARDown-0.0305280434
GSE13712_STATICUp0.0680866755
GSE19018Down-2.1037977998
GSE19899_A1Up0.1623928241
GSE19899_A2Down-0.5549686488
PubMed_21979375_A1Up0.3958459194
PubMed_21979375_A2Up0.2996672665
GSE35957Down-0.9094584248
GSE36640Down-0.0072011183
GSE54402Down-0.0455893500
GSE9593Up0.0379062235
GSE43922Up0.8878254422
GSE24585Down-1.8052223351
GSE37065Up0.1182170191
GSE28863_A1Up1.8783704516
GSE28863_A2Up2.4216861419
GSE28863_A3Up1.3876232239
GSE28863_A4Down-0.1321506011
GSE48662Down-0.2928842765

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT000666Immunohistochemistry//Luciferase reporter assay//Microarray//Microarray;OtherFunctional MTI18185580
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

22362388Levels of pulmonary injury, assessed by tenascin-C mRNA expression and CD44v10 detection, were significantly increased at Day 21 after injury in WT mice, an effect significantly attenuated in cav-1(-/-) mice
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