HCSGD entry for IFNB1

1. General information

Official gene symbolIFNB1
Entrez ID3456
Gene full nameinterferon, beta 1, fibroblast
Other gene symbolsIFB IFF IFNB
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002250Adaptive immune responseIEAbiological_process
GO:0002286T cell activation involved in immune responseIBAbiological_process
GO:0002312B cell activation involved in immune responseIMPbiological_process
GO:0002323Natural killer cell activation involved in immune responseIBAbiological_process
GO:0005125Cytokine activityIBA IDAmolecular_function
GO:0005132Type I interferon receptor bindingNASmolecular_function
GO:0005576Extracellular regionIC TAScellular_component
GO:0005615Extracellular spaceIBAcellular_component
GO:0006919Activation of cysteine-type endopeptidase activity involved in apoptotic processIDA NASbiological_process
GO:0006959Humoral immune responseIBAbiological_process
GO:0007166Cell surface receptor signaling pathwayTASbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0009615Response to virusNASbiological_process
GO:0019221Cytokine-mediated signaling pathwayIBA TASbiological_process
GO:0030101Natural killer cell activationNASbiological_process
GO:0030183B cell differentiationIBAbiological_process
GO:0033141Positive regulation of peptidyl-serine phosphorylation of STAT proteinIDAbiological_process
GO:0042100B cell proliferationNASbiological_process
GO:0042742Defense response to bacteriumIEAbiological_process
GO:0043330Response to exogenous dsRNAIDAbiological_process
GO:0045071Negative regulation of viral genome replicationIDAbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045089Positive regulation of innate immune responseNASbiological_process
GO:0045343Regulation of MHC class I biosynthetic processNASbiological_process
GO:0045581Negative regulation of T cell differentiationIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0046597Negative regulation of viral entry into host cellNASbiological_process
GO:0051607Defense response to virusTASbiological_process
GO:0060337Type I interferon signaling pathwayTASbiological_process
GO:0060338Regulation of type I interferon-mediated signaling pathwayTASbiological_process
GO:0071360Cellular response to exogenous dsRNATASbiological_process
GO:0097194Execution phase of apoptosisIDAbiological_process
GO:2000552Negative regulation of T-helper 2 cell cytokine productionIDAbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.51963265830.78517886860.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0249392766
GSE13712_SHEARDown-0.1030767570
GSE13712_STATICUp0.2604059220
GSE19018Down-0.0089434040
GSE19899_A1Down-0.0070149926
GSE19899_A2Down-0.0273641502
PubMed_21979375_A1Up0.0219866784
PubMed_21979375_A2Down-0.2949382856
GSE35957Down-0.1424927581
GSE36640Up0.0715166536
GSE54402Up0.1141328519
GSE9593Down-0.1024507456
GSE43922Up0.0194052339
GSE24585Up0.1089286120
GSE37065Up0.0780541177
GSE28863_A1Up0.1023826505
GSE28863_A2Up0.3140326924
GSE28863_A3Up0.0983308474
GSE28863_A4Up0.0882292139
GSE48662Up0.0250548853

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Beta-D-GlucoseDB02379 EXPT00685 | EXPT00455 | EXPT01603

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-let-7b-5pMIMAT0000063MIRT004614ELISA//Luciferase reporter assay//qRT-PCRFunctional MTI20130213
hsa-miR-26a-5pMIMAT0000082MIRT004615ELISA//Luciferase reporter assay//qRT-PCRFunctional MTI20130213
hsa-miR-145-5pMIMAT0000437MIRT004616ELISA//Luciferase reporter assay//qRT-PCRFunctional MTI20130213
hsa-miR-34a-5pMIMAT0000255MIRT004617ELISA//Luciferase reporter assay//qRT-PCRFunctional MTI20130213
Entries Per Page
Displaying Page of
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 10 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

27063514DDR-induced signaling in cells activates the ATM-p53 and ATM-IKKalpha/beta-interferon (IFN)-beta signaling pathways, thus leading to an induction of the p53 and IFN-inducible IFI16 gene
27063514Further, upon DNA-damage, DNA accumulates in the cytoplasm, thereby inducing the IFI16 protein and STING-dependent IFN-beta production and activation of the IFI16 inflammasome, resulting in the production of proinflammatory cytokines (e
27039820We here aimed to investigate cellular senescence in immortalized cholangiocyte and cholangiocarcinoma cell lines using five different inducing agents: 5-aza-2'deoxycytidine, bromodeoxyuridine, interferons (IFNbeta and IFNgamma), and hydrogen peroxide
22864395Significantly, higher IFNbeta and chemokine gene transcripts have been observed, together with increased STAT1 and decreased STAT3 and NF-kappaB signaling activities
22864395The knockdown of Maml1 transcription in the human melanoma cell line M537 also results in senescence, IFNbeta upregulation, increased chemokine gene expression, and greater NK and CD8(+) T cell migration in a transwell system
22615843In particular, upon longer IFN-beta treatments, cutaneous HPV38 expressing cells undergo senescence
22615843IFN-beta appears to induce senescence by upregulating the expression of the tumor suppressor PML, a well known IFN-induced gene
22615843IFN-beta treatment leads to a modulation of p53 phosphorylation and acetylation status and a reduction in the expression of the p53 dominant negative DeltaNp73
21471287On sensing dsDNA, the IFI16 protein induces the expression of IFN-beta whereas the AIM2 protein forms an inflammasome, which promotes the secretion of IL-1beta
21471287The IFN-beta treatment of the young HDFs, which induced the expression of IFI16 and AIM2 proteins, activated a DNA damage response and also increased basal levels of IL-1beta
19802007JAK1/STAT-activating ligands, interleukin 10 (IL10), IL20, IL24, interferon gamma (IFNgamma), IFNbeta and IL6, were also expressed by senescent cells, supporting autocrine/paracrine activation of JAK1/STAT
16989575PTX1(ERGIC2)-VP22 fusion protein upregulates interferon-beta in prostate cancer cell line PC-3
16989575Gene expression microarray analyses showed that interferon-beta (IFN-beta) and a number of IFN-inducible genes, among other genes, were upregulated by the PTX1-VP22 fusion protein
16989575Upregulation of IFN-beta was confirmed by RTPCR and promoter-reporter assay
16989575However, the upregulation of IFN-beta by the PTX1-VP22 fusion protein was not due to nuclear translocation of the PTX1 luminal domain
14563561These studies demonstrate that IFN-beta controls hPNPase(old-35) expression by transcriptional modulation rather than by altering mRNA stability
14563561Transcriptional activation of hPNPase(old-35) by IFN-beta is primarily mediated by the interferon stimulatory response element (ISRE) present in its promoter
9144735Non-polarized secretion of mouse interferon-beta from gene-transferred human intestinal Caco-2 cells
9144735To this end, Caco-2 cells derived from human colon carcinoma were transfected with a mouse interferon-beta (IFN-beta) expression vector and several stable sublines were established; this hetero-specific cytokine allows unexpected cellular effects to be avoided
9144735METHODS: The secretion polarity of mouse IFN-beta in its gene-transduced Caco-2 sublines was studied in a bicameral culture system in which the chambers were separated by microporous filters
9144735RESULTS: Mouse IFN-beta was secreted to the same extent from both apical and basolateral surfaces of the transduced cells regardless of cell aging
8376318Effects of tumor necrosis factor and interferon-beta on proliferation and epidermal growth factor binding in young and senescent WI-38 cells
8376318We have examined the effects of TNF and IFN-beta on the proliferation of WI-38 cells in a serum-free, growth factor-supplemented medium and in serum-containing medium
8376318IFN-beta inhibits DNA synthesis 60 to 70% in both young and senescent cells
8376318TNF and IFN-beta together have a synergistic effect and completely inhibit growth factor-stimulated DNA synthesis in young cells
8376318IFN-beta has little or no effect on EGF binding either alone or in combination with TNF
Entries Per Page
Displaying Page of