HCSGD entry for IL17A
1. General information
| Official gene symbol | IL17A |
|---|---|
| Entrez ID | 3605 |
| Gene full name | interleukin 17A |
| Other gene symbols | CTLA8 IL-17 IL-17A IL17 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005125 | Cytokine activity | IEA | molecular_function |
| GO:0005615 | Extracellular space | IEA | cellular_component |
| GO:0006486 | Protein glycosylation | TAS | biological_process |
| GO:0006915 | Apoptotic process | TAS | biological_process |
| GO:0006954 | Inflammatory response | IEA | biological_process |
| GO:0006955 | Immune response | TAS | biological_process |
| GO:0007267 | Cell-cell signaling | TAS | biological_process |
| GO:0008219 | Cell death | TAS | biological_process |
| GO:0009897 | External side of plasma membrane | IEA | cellular_component |
| GO:0032747 | Positive regulation of interleukin-23 production | IDA | biological_process |
| GO:0045672 | Positive regulation of osteoclast differentiation | IDA | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0071347 | Cellular response to interleukin-1 | IEA | biological_process |
| GO:0072537 | Fibroblast activation | IDA | biological_process |
| GO:1900017 | Positive regulation of cytokine production involved in inflammatory response | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5521366134 | 0.9125690969 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1720705523 |
| GSE13712_SHEAR | Down | -0.0243376658 |
| GSE13712_STATIC | Up | 0.0682170466 |
| GSE19018 | Up | 0.0922758658 |
| GSE19899_A1 | Up | 0.1462003642 |
| GSE19899_A2 | Up | 0.1067909444 |
| PubMed_21979375_A1 | Down | -0.0323319056 |
| PubMed_21979375_A2 | Up | 0.0535236478 |
| GSE35957 | Up | 0.0493816264 |
| GSE36640 | Up | 0.1339924820 |
| GSE54402 | Up | 0.0402478995 |
| GSE9593 | Up | 0.2403273427 |
| GSE43922 | Up | 0.1137105580 |
| GSE24585 | Down | -0.1038542752 |
| GSE37065 | Up | 0.1069025325 |
| GSE28863_A1 | Down | -0.1435585665 |
| GSE28863_A2 | Up | 0.0123119231 |
| GSE28863_A3 | Up | 0.1645340003 |
| GSE28863_A4 | Up | 0.0284205867 |
| GSE48662 | Down | -0.0078537724 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT016706 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 21300823 | These subsets exhibited differences in suppressive capacity, ability to secrete IL-10 and IL-17, Foxp3 gene methylation, cellular senescence, and frequency in neonatal and adult blood |
| 21300823 | In contrast, whereas the CD127(+)HLA-DR(-) cells also suppressed proliferation of effector cells, they could alternate between suppression or secretion of IL-17 depending upon the stimulation signals |
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