HCSGD entry for INPP5D

1. General information

Official gene symbolINPP5D
Entrez ID3635
Gene full nameinositol polyphosphate-5-phosphatase, 145kDa
Other gene symbolsSHIP SHIP-1 SHIP1 SIP-145 hp51CN
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004445Inositol-polyphosphate 5-phosphatase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005829CytosolTAScellular_component
GO:0006644Phospholipid metabolic processTASbiological_process
GO:0006661Phosphatidylinositol biosynthetic processTASbiological_process
GO:0006796Phosphate-containing compound metabolic processTASbiological_process
GO:0006915Apoptotic processIEAbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008340Determination of adult lifespanIEAbiological_process
GO:0009968Negative regulation of signal transductionIEAbiological_process
GO:0016020MembraneIEAcellular_component
GO:0016064Immunoglobulin mediated immune responseIEAbiological_process
GO:0017124SH3 domain bindingIEAmolecular_function
GO:0030889Negative regulation of B cell proliferationIEAbiological_process
GO:0034594Phosphatidylinositol trisphosphate phosphatase activityIEAmolecular_function
GO:0035556Intracellular signal transductionIEAbiological_process
GO:0043065Positive regulation of apoptotic processIEAbiological_process
GO:0043647Inositol phosphate metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045409Negative regulation of interleukin-6 biosynthetic processIEAbiological_process
GO:0045579Positive regulation of B cell differentiationIEAbiological_process
GO:0045648Positive regulation of erythrocyte differentiationIEAbiological_process
GO:0045656Negative regulation of monocyte differentiationIEAbiological_process
GO:0045659Negative regulation of neutrophil differentiationIEAbiological_process
GO:0045671Negative regulation of osteoclast differentiationIEAbiological_process
GO:0045779Negative regulation of bone resorptionIEAbiological_process
GO:0046856Phosphatidylinositol dephosphorylationIEAbiological_process
GO:0050777Negative regulation of immune responseIEAbiological_process
GO:0050852T cell receptor signaling pathwayTASbiological_process
GO:0050900Leukocyte migrationTASbiological_process
GO:0051425PTB domain bindingIEAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.77047826830.34436666160.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0555552202
GSE13712_SHEARDown-0.8940864227
GSE13712_STATICDown-0.3660356548
GSE19018Up0.0336748477
GSE19899_A1Up0.1300083985
GSE19899_A2Down-0.0114635102
PubMed_21979375_A1Up0.0208401154
PubMed_21979375_A2Down-0.0178336898
GSE35957Up0.0627226974
GSE36640Down-0.0243892040
GSE54402Down-0.1045493011
GSE9593Up0.0075227196
GSE43922Up0.0187455711
GSE24585Up0.4011048009
GSE37065Up0.0778835324
GSE28863_A1Down-0.3408924961
GSE28863_A2Down-0.2141469420
GSE28863_A3Up0.2748144129
GSE28863_A4Up0.1280348653
GSE48662Down-0.0542728665

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-155-5pMIMAT0000646MIRT000631qRT-PCR//Luciferase reporter assay//Western blotFunctional MTI19890474
hsa-miR-155-5pMIMAT0000646MIRT000631Luciferase reporter assay//Western blot//Reporter assayFunctional MTI20041145
hsa-miR-155-5pMIMAT0000646MIRT000631Luciferase reporter assay//Reporter assay;Western blot;qRT-PCR;OtherFunctional MTI19359473
hsa-miR-155-5pMIMAT0000646MIRT000631GFP reporter assay//Luciferase reporter assay//Northern blot//qRT-PCR//Western blotFunctional MTI19641183
hsa-miR-26b-5pMIMAT0000083MIRT030268MicroarrayFunctional MTI (Weak)19088304
hsa-miR-93-3pMIMAT0004509MIRT038735CLASHFunctional MTI (Weak)23622248
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  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-155-5pMIMAT00006461hsa-miR-155{Western blot}{overexpression}19890474
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.