HCSGD entry for ITPR3

1. General information

Official gene symbolITPR3
Entrez ID3710
Gene full nameinositol 1,4,5-trisphosphate receptor, type 3
Other gene symbolsIP3R IP3R3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000822Inositol hexakisphosphate bindingISSmolecular_function
GO:0005218Intracellular ligand-gated calcium channel activityISSmolecular_function
GO:0005220Inositol 1,4,5-trisphosphate-sensitive calcium-release channel activityIDA ISSmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005640Nuclear outer membraneISScellular_component
GO:0005654NucleoplasmIEAcellular_component
GO:0005730NucleolusIEAcellular_component
GO:0005737CytoplasmISScellular_component
GO:0005783Endoplasmic reticulumISScellular_component
GO:0005789Endoplasmic reticulum membraneIDA ISS TAScellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0005887Integral component of plasma membraneIDAcellular_component
GO:0005903Brush borderISScellular_component
GO:0006112Energy reserve metabolic processTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007186G-protein coupled receptor signaling pathwayISSbiological_process
GO:0007202Activation of phospholipase C activityTASbiological_process
GO:0007204Positive regulation of cytosolic calcium ion concentrationISSbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0007613MemoryIEAbiological_process
GO:0008543Fibroblast growth factor receptor signaling pathwayTASbiological_process
GO:0030168Platelet activationTASbiological_process
GO:0031095Platelet dense tubular network membraneTAScellular_component
GO:0035091Phosphatidylinositol bindingIEAmolecular_function
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosisTASbiological_process
GO:0043025Neuronal cell bodyISScellular_component
GO:0043209Myelin sheathISScellular_component
GO:0043235Receptor complexIDAcellular_component
GO:0043533Inositol 1,3,4,5 tetrakisphosphate bindingISSmolecular_function
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045177Apical part of cellISScellular_component
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0050796Regulation of insulin secretionTASbiological_process
GO:0050913Sensory perception of bitter tasteIEAbiological_process
GO:0050916Sensory perception of sweet tasteIEAbiological_process
GO:0050917Sensory perception of umami tasteIEAbiological_process
GO:0051260Protein homooligomerizationISSbiological_process
GO:0051291Protein heterooligomerizationISSbiological_process
GO:0051592Response to calcium ionIDAbiological_process
GO:0060291Long-term synaptic potentiationIEAbiological_process
GO:0060402Calcium ion transport into cytosolISSbiological_process
GO:0070679Inositol 1,4,5 trisphosphate bindingIDAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.23309400480.22587916490.91676913650.9142496540

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0246404550
GSE13712_SHEARUp0.2481097294
GSE13712_STATICUp0.2266122959
GSE19018Up0.0433678027
GSE19899_A1Down-0.0494540202
GSE19899_A2Down-0.6458304866
PubMed_21979375_A1Down-0.6556276265
PubMed_21979375_A2Up0.1934516251
GSE35957Down-0.5366999657
GSE36640Down-0.1734388304
GSE54402Up0.2584213839
GSE9593Up0.6132912165
GSE43922Down-0.4651009217
GSE24585Down-0.5561814084
GSE37065Up0.4851486716
GSE28863_A1Down-0.0679139195
GSE28863_A2Up0.6010903435
GSE28863_A3Up0.1990989272
GSE28863_A4Down-0.0758641747
GSE48662Up0.1735931819

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-1226-3pMIMAT0005577MIRT036459CLASHFunctional MTI (Weak)23622248
hsa-miR-877-3pMIMAT0004950MIRT036993CLASHFunctional MTI (Weak)23622248
hsa-miR-23b-3pMIMAT0000418MIRT046325CLASHFunctional MTI (Weak)23622248
hsa-miR-96-5pMIMAT0000095MIRT048721CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049194CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.