HCSGD entry for JAK3

1. General information

Official gene symbolJAK3
Entrez ID3718
Gene full nameJanus kinase 3
Other gene symbolsJAK-3 JAK3_HUMAN JAKL L-JAK LJAK
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002731Negative regulation of dendritic cell cytokine productionISSbiological_process
GO:0004713Protein tyrosine kinase activityISS TASmolecular_function
GO:0004715Non-membrane spanning protein tyrosine kinase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005829CytosolTAScellular_component
GO:0005856CytoskeletonIEAcellular_component
GO:0006468Protein phosphorylationTASbiological_process
GO:0007167Enzyme linked receptor protein signaling pathwayISSbiological_process
GO:0007260Tyrosine phosphorylation of STAT proteinTASbiological_process
GO:0007262STAT protein import into nucleusTASbiological_process
GO:0012505Endomembrane systemIEAcellular_component
GO:0016020MembraneIEAcellular_component
GO:0018108Peptidyl-tyrosine phosphorylationISSbiological_process
GO:0019903Protein phosphatase bindingIPImolecular_function
GO:0030183B cell differentiationISSbiological_process
GO:0032693Negative regulation of interleukin-10 productionISSbiological_process
GO:0032695Negative regulation of interleukin-12 productionISSbiological_process
GO:0035556Intracellular signal transductionISSbiological_process
GO:0035771Interleukin-4-mediated signaling pathwayIDAbiological_process
GO:0043029T cell homeostasisISS TASbiological_process
GO:0045087Innate immune responseIEAbiological_process
GO:0045221Negative regulation of FasL biosynthetic processISSbiological_process
GO:0045626Negative regulation of T-helper 1 cell differentiationISSbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0050868Negative regulation of T cell activationISSbiological_process
GO:0060397JAK-STAT cascade involved in growth hormone signaling pathwayTASbiological_process
GO:0070232Regulation of T cell apoptotic processISSbiological_process
GO:0070244Negative regulation of thymocyte apoptotic processISSbiological_process
GO:0070669Response to interleukin-2TASbiological_process
GO:0070670Response to interleukin-4IDAbiological_process
GO:0070672Response to interleukin-15TASbiological_process
GO:0071104Response to interleukin-9TASbiological_process
GO:2000670Positive regulation of dendritic cell apoptotic processIEAbiological_process
GO:2001241Positive regulation of extrinsic apoptotic signaling pathway in absence of ligandIEAbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.71996737970.75994484250.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0710077046
GSE13712_SHEARDown-0.1332321325
GSE13712_STATICDown-0.1566486136
GSE19018Up0.0083742714
GSE19899_A1Up0.0755300249
GSE19899_A2Up0.1343807941
PubMed_21979375_A1Up0.0684919933
PubMed_21979375_A2Down-0.0409923293
GSE35957Up0.3128686758
GSE36640Down-0.2155204699
GSE54402Up0.0347872154
GSE9593Down-0.0768887508
GSE43922Down-0.0352666781
GSE24585Up0.1636997870
GSE37065Up0.0041075755
GSE28863_A1Up0.0448377994
GSE28863_A2Up0.2587731941
GSE28863_A3Up0.0920608339
GSE28863_A4Up0.0024217417
GSE48662Up0.1106728698

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

2-(1,1-DIMETHYLETHYL)9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLIN-7-ONEDB04716 -
3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrileDB08183 -
TofacitinibDB08895 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT017636MicroarrayFunctional MTI (Weak)18185580
Entries Per Page
Displaying Page of
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.