HCSGD entry for KCNA1

1. General information

Official gene symbolKCNA1
Entrez ID3736
Gene full namepotassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)
Other gene symbolsAEMK EA1 HBK1 HUK1 KV1.1 MBK1 MK1 RBK1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005251Delayed rectifier potassium channel activityIBAmolecular_function
GO:0005267Potassium channel activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005886Plasma membraneTAScellular_component
GO:0006813Potassium ion transportTASbiological_process
GO:0007268Synaptic transmissionTASbiological_process
GO:0008076Voltage-gated potassium channel complexIEAcellular_component
GO:0015079Potassium ion transmembrane transporter activityTASmolecular_function
GO:0016324Apical plasma membraneIEAcellular_component
GO:0030425DendriteIEAcellular_component
GO:0043025Neuronal cell bodyIEAcellular_component
GO:0044224Juxtaparanode region of axonISScellular_component
GO:0051260Protein homooligomerizationIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.83107328370.60402586530.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0381621780
GSE13712_SHEARDown-0.2421828894
GSE13712_STATICDown-0.1055662334
GSE19018Up0.1825188049
GSE19899_A1Down-0.0041767549
GSE19899_A2Down-0.0630297574
PubMed_21979375_A1Up0.0448443234
PubMed_21979375_A2Up0.0725591400
GSE35957Down-0.0075168451
GSE36640Up0.0301854934
GSE54402Down-0.0881011532
GSE9593Down-0.0169963312
GSE43922Up0.1380504558
GSE24585Up0.0133214521
GSE37065Down-0.0586352857
GSE28863_A1Down-0.1577605710
GSE28863_A2Up0.0348507329
GSE28863_A3Up0.2293494741
GSE28863_A4Down-0.1200878686
GSE48662Up0.0561785655

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

EnfluraneDB00228 APRD00234
IsofluraneDB00753 APRD00212
MethoxyfluraneDB01028 APRD00744
NifedipineDB01115 APRD00590
DesfluraneDB01189 APRD00907
SevofluraneDB01236 APRD00219
DalfampridineDB06637 -

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

23774215Potassium channel KCNA1 modulates oncogene-induced senescence and transformation
23774215We carried out a loss-of-function genetic screen that identified the potassium channel KCNA1 as a determinant of OIS escape that can license tumor growth
23774215Oncogenic stress triggers an increase in KCNA1 expression and its relocation from the cytoplasm to the membrane
23774215Mechanistically, this relocation is due to a loss of protein kinase A (PKA)-induced phosphorylation at residue S446 of KCNA1
23774215Accordingly, sustaining PKA activity or expressing a KCNA1 phosphomimetic mutant maintained KCNA1 in the cytoplasm and caused escape from OIS
23774215KCNA1 relocation to the membrane induced a change in membrane potential that invariably resulted in cellular senescence
23774215Restoring KCNA1 expression in transformation-competent cells triggered variation in membrane potential and blocked RAS-induced transformation, and PKA activation suppressed both effects
23774215Furthermore, KCNA1 expression was reduced in human cancers, and this decrease correlated with an increase in breast cancer aggressiveness
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