HCSGD entry for KIT

1. General information

Official gene symbol	KIT
Entrez ID	3815
Gene full name	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
Other gene symbols	C-Kit CD117 PBT SCFR
Links to Entrez Gene	Links to Entrez Gene

2. Neighbors in the network

This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID	GO term	Evidence	Category
GO:0000187	Activation of MAPK activity	IDA	biological_process
GO:0001541	Ovarian follicle development	ISS	biological_process
GO:0001669	Acrosomal vesicle	IEA	cellular_component
GO:0002020	Protease binding	IEA	molecular_function
GO:0002318	Myeloid progenitor cell differentiation	IEA	biological_process
GO:0002320	Lymphoid progenitor cell differentiation	IEA	biological_process
GO:0002327	Immature B cell differentiation	ISS	biological_process
GO:0002371	Dendritic cell cytokine production	ISS	biological_process
GO:0002551	Mast cell chemotaxis	IDA	biological_process
GO:0004713	Protein tyrosine kinase activity	TAS	molecular_function
GO:0004714	Transmembrane receptor protein tyrosine kinase activity	IDA	molecular_function
GO:0004716	Receptor signaling protein tyrosine kinase activity	IEA	molecular_function
GO:0005020	Stem cell factor receptor activity	IEA	molecular_function
GO:0005515	Protein binding	IPI	molecular_function
GO:0005524	ATP binding	IEA	molecular_function
GO:0005615	Extracellular space	IDA	cellular_component
GO:0005634	Nucleus	IDA	cellular_component
GO:0005737	Cytoplasm	IDA	cellular_component
GO:0005886	Plasma membrane	TAS	cellular_component
GO:0006687	Glycosphingolipid metabolic process	IEA	biological_process
GO:0006954	Inflammatory response	ISS	biological_process
GO:0007165	Signal transduction	TAS	biological_process
GO:0007173	Epidermal growth factor receptor signaling pathway	TAS	biological_process
GO:0007283	Spermatogenesis	ISS TAS	biological_process
GO:0007286	Spermatid development	IEA	biological_process
GO:0008284	Positive regulation of cell proliferation	IEA	biological_process
GO:0008354	Germ cell migration	IEA	biological_process
GO:0008360	Regulation of cell shape	ISS	biological_process
GO:0008542	Visual learning	IEA	biological_process
GO:0008543	Fibroblast growth factor receptor signaling pathway	TAS	biological_process
GO:0008584	Male gonad development	IEP	biological_process
GO:0009897	External side of plasma membrane	IEA	cellular_component
GO:0009898	Cytoplasmic side of plasma membrane	IEA	cellular_component
GO:0010628	Positive regulation of gene expression	IEA	biological_process
GO:0010863	Positive regulation of phospholipase C activity	TAS	biological_process
GO:0014068	Positive regulation of phosphatidylinositol 3-kinase signaling	TAS	biological_process
GO:0016021	Integral component of membrane	IEA	cellular_component
GO:0018108	Peptidyl-tyrosine phosphorylation	IDA	biological_process
GO:0019221	Cytokine-mediated signaling pathway	IDA	biological_process
GO:0019827	Stem cell maintenance	TAS	biological_process
GO:0019955	Cytokine binding	IDA	molecular_function
GO:0023014	Signal transduction by phosphorylation	TAS	biological_process
GO:0030032	Lamellipodium assembly	ISS	biological_process
GO:0030097	Hemopoiesis	TAS	biological_process
GO:0030217	T cell differentiation	ISS	biological_process
GO:0030218	Erythrocyte differentiation	ISS	biological_process
GO:0030318	Melanocyte differentiation	ISS TAS	biological_process
GO:0030335	Positive regulation of cell migration	IEA	biological_process
GO:0031274	Positive regulation of pseudopodium assembly	IEA	biological_process
GO:0031532	Actin cytoskeleton reorganization	IDA	biological_process
GO:0032762	Mast cell cytokine production	IDA	biological_process
GO:0035019	Somatic stem cell maintenance	IEA	biological_process
GO:0035162	Embryonic hemopoiesis	ISS	biological_process
GO:0035234	Ectopic germ cell programmed cell death	IEA	biological_process
GO:0035855	Megakaryocyte development	ISS	biological_process
GO:0038093	Fc receptor signaling pathway	IDA	biological_process
GO:0038095	Fc-epsilon receptor signaling pathway	TAS	biological_process
GO:0038109	Kit signaling pathway	IDA	biological_process
GO:0038162	Erythropoietin-mediated signaling pathway	ISS	biological_process
GO:0042127	Regulation of cell proliferation	TAS	biological_process
GO:0042511	Positive regulation of tyrosine phosphorylation of Stat1 protein	IMP	biological_process
GO:0042517	Positive regulation of tyrosine phosphorylation of Stat3 protein	IMP	biological_process
GO:0042523	Positive regulation of tyrosine phosphorylation of Stat5 protein	IMP	biological_process
GO:0042629	Mast cell granule	IMP	cellular_component
GO:0042803	Protein homodimerization activity	IPI	molecular_function
GO:0043069	Negative regulation of programmed cell death	IEA	biological_process
GO:0043303	Mast cell degranulation	IMP	biological_process
GO:0043410	Positive regulation of MAPK cascade	IMP	biological_process
GO:0043473	Pigmentation	ISS	biological_process
GO:0043552	Positive regulation of phosphatidylinositol 3-kinase activity	TAS	biological_process
GO:0045087	Innate immune response	TAS	biological_process
GO:0045747	Positive regulation of Notch signaling pathway	IEA	biological_process
GO:0046427	Positive regulation of JAK-STAT cascade	IMP	biological_process
GO:0046777	Protein autophosphorylation	IDA	biological_process
GO:0046872	Metal ion binding	IEA	molecular_function
GO:0048011	Neurotrophin TRK receptor signaling pathway	TAS	biological_process
GO:0048015	Phosphatidylinositol-mediated signaling	TAS	biological_process
GO:0048070	Regulation of developmental pigmentation	IEA	biological_process
GO:0048103	Somatic stem cell division	IEA	biological_process
GO:0048170	Positive regulation of long-term neuronal synaptic plasticity	IEA	biological_process
GO:0048565	Digestive tract development	ISS	biological_process
GO:0048863	Stem cell differentiation	ISS	biological_process
GO:0050673	Epithelial cell proliferation	IEA	biological_process
GO:0050910	Detection of mechanical stimulus involved in sensory perception of sound	ISS	biological_process
GO:0051091	Positive regulation of sequence-specific DNA binding transcription factor activity	IMP	biological_process
GO:0060326	Cell chemotaxis	IDA	biological_process
GO:0060374	Mast cell differentiation	ISS TAS	biological_process
GO:0070662	Mast cell proliferation	TAS	biological_process
GO:0097067	Cellular response to thyroid hormone stimulus	IEA	biological_process
GO:0097324	Melanocyte migration	ISS	biological_process
GO:0097326	Melanocyte adhesion	ISS	biological_process

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4. Expression levels in datasets

Meta-analysis result

p-value up	p-value down	FDR up	FDR down
0.5627288857	0.0002383990	0.9999902473	0.0271017241

Individual experiment result
( "-" represent NA in the specific microarray platform )

Data source	Up or down	Log fold change
GSE11954	Down	-0.0606214151
GSE13712_SHEAR	Down	-0.2757473075
GSE13712_STATIC	Down	-2.7071887385
GSE19018	Up	0.7363710387
GSE19899_A1	Down	-1.0638378602
GSE19899_A2	Down	-2.9850807599
PubMed_21979375_A1	Down	-5.2818009019
PubMed_21979375_A2	Down	-2.4559073955
GSE35957	Up	0.2194112769
GSE36640	Down	-1.5963188140
GSE54402	Down	-2.6690479557
GSE9593	Up	0.1234963706
GSE43922	Down	-4.2120925181
GSE24585	Up	0.0654072139
GSE37065	Up	0.0011285642
GSE28863_A1	Down	-0.1226205104
GSE28863_A2	Up	1.4888995534
GSE28863_A3	Up	0.2934652106
GSE28863_A4	Down	-0.0077943961
GSE48662	Down	-0.0106037456

5. Regulation relationships with compounds/drugs/microRNAs

Compounds

Not regulated by compounds

Drugs

Name	Drug	Accession number
Sorafenib	DB00398	APRD01304 \| DB07438
Imatinib	DB00619	APRD01028 \| EXPT02967 \| DB03261
Dasatinib	DB01254	-
Sunitinib	DB01268	DB07417
Phosphonotyrosine	DB01962	EXPT02687
Nilotinib	DB04868	-
XL820	DB05146	-
XL184	DB05153	-
MP470	DB05216	-
OSI-930	DB05913	-
ABT-869	DB06080	-
Pazopanib	DB06589	-
Regorafenib	DB08896	-
Ponatinib	DB08901	-
Lenvatinib	DB09078	-

MicroRNAs

mirTarBase

MiRNA_name	mirBase ID	miRTarBase ID	Experiment	Support type	References (Pubmed ID)
hsa-miR-222-3p	MIMAT0000279	MIRT001779	qRT-PCR//Western blot	Functional MTI	18417445
hsa-miR-222-3p	MIMAT0000279	MIRT001779	Luciferase reporter assay	Functional MTI	18246122
hsa-miR-222-3p	MIMAT0000279	MIRT001779	Luciferase reporter assay	Functional MTI	18983236
hsa-miR-222-3p	MIMAT0000279	MIRT001779	Northern blot//qRT-PCR//Western blot	Functional MTI	16365291
hsa-miR-222-3p	MIMAT0000279	MIRT001779	Reporter assay	Functional MTI	16330772
hsa-miR-221-3p	MIMAT0000278	MIRT001780	Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	19088079
hsa-miR-221-3p	MIMAT0000278	MIRT001780	qRT-PCR//Western blot	Functional MTI	19126397
hsa-miR-221-3p	MIMAT0000278	MIRT001780	Luciferase reporter assay	Functional MTI	18246122
hsa-miR-221-3p	MIMAT0000278	MIRT001780	Luciferase reporter assay	Functional MTI	18983236
hsa-miR-221-3p	MIMAT0000278	MIRT001780	qRT-PCR//Western blot	Functional MTI	18417445
hsa-miR-221-3p	MIMAT0000278	MIRT001780	Northern blot//qRT-PCR//Western blot	Functional MTI	16365291
hsa-miR-221-3p	MIMAT0000278	MIRT001780	Reporter assay;Microarray	Functional MTI	20018759
hsa-miR-221-3p	MIMAT0000278	MIRT001780	Reporter assay	Functional MTI	16330772
hsa-miR-146b-5p	MIMAT0002809	MIRT005371	Northern blot//qRT-PCR//Western blot	Functional MTI	16365291
hsa-miR-335-5p	MIMAT0000765	MIRT017735	Microarray	Functional MTI (Weak)	18185580
hsa-miR-186-5p	MIMAT0000456	MIRT021165	Sequencing	Functional MTI (Weak)	20371350
hsa-miR-181c-5p	MIMAT0000258	MIRT047222	CLASH	Functional MTI (Weak)	23622248

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mirRecord

MicroRNA name	mirBase ID	Target site number	MiRNA mature ID	Test method inter	MiRNA regulation site	Pubmed ID
hsa-miR-221-3p	MIMAT0000278	1	hsa-miR-221	{Western blot}	{overexpression by mature miRNA transfection}	16330772
hsa-miR-222-3p	MIMAT0000279	1	hsa-miR-222	{Western blot}	{overexpression by mature miRNA transfection}	16330772
hsa-miR-221-3p	MIMAT0000278	NA	hsa-miR-221	{Western blot}	{endogenous}	19126397

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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.

PubMed ID of the article	Sentenece the gene occurs
17016587	F6 cells maintained the same properties as of MSCs, such as negativity for both CD117 and vimentin

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Navigator

1.General information
2.Neighbors in the network
3.Gene Ontology Annotation
4.Expression levels
5.Regulation
6.Text-mining results

HCSGD entry for KIT

1. General information

2. Neighbors in the network

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

4. Expression levels in datasets

Meta-analysis result

Individual experiment result ( "-" represent NA in the specific microarray platform )

( "-" represent NA in the specific microarray platform )

5. Regulation relationships with compounds/drugs/microRNAs

Compounds

Drugs

Name

Drug

Accession number

MicroRNAs

mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.

PubMed ID of the article

Sentenece the gene occurs

Navigator

Individual experiment result
( "-" represent NA in the specific microarray platform )