HCSGD entry for LAMC1
1. General information
| Official gene symbol | LAMC1 |
|---|---|
| Entrez ID | 3915 |
| Gene full name | laminin, gamma 1 (formerly LAMB2) |
| Other gene symbols | LAMB2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005201 | Extracellular matrix structural constituent | IMP | molecular_function |
| GO:0005576 | Extracellular region | TAS | cellular_component |
| GO:0005604 | Basement membrane | IDA | cellular_component |
| GO:0005606 | Laminin-1 complex | IEA NAS TAS | cellular_component |
| GO:0005615 | Extracellular space | NAS | cellular_component |
| GO:0006461 | Protein complex assembly | IDA | biological_process |
| GO:0007155 | Cell adhesion | IDA | biological_process |
| GO:0007411 | Axon guidance | TAS | biological_process |
| GO:0007492 | Endoderm development | TAS | biological_process |
| GO:0016477 | Cell migration | IMP | biological_process |
| GO:0022617 | Extracellular matrix disassembly | IMP | biological_process |
| GO:0030198 | Extracellular matrix organization | TAS | biological_process |
| GO:0031012 | Extracellular matrix | IDA ISS | cellular_component |
| GO:0031175 | Neuron projection development | IEA | biological_process |
| GO:0031581 | Hemidesmosome assembly | IMP | biological_process |
| GO:0034446 | Substrate adhesion-dependent cell spreading | IDA | biological_process |
| GO:0043208 | Glycosphingolipid binding | IEA | molecular_function |
| GO:0043259 | Laminin-10 complex | IEA TAS | cellular_component |
| GO:0043260 | Laminin-11 complex | TAS | cellular_component |
| GO:0050679 | Positive regulation of epithelial cell proliferation | TAS | biological_process |
| GO:0070062 | Extracellular vesicular exosome | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0473371794 | 0.0524451997 | 0.4812521823 | 0.4315130041 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.5491306150 |
| GSE13712_SHEAR | Up | 0.1058656877 |
| GSE13712_STATIC | Down | -0.0203500888 |
| GSE19018 | Up | 1.0404763818 |
| GSE19899_A1 | Down | -0.3538518792 |
| GSE19899_A2 | Down | -0.6160947518 |
| PubMed_21979375_A1 | Down | -1.3854729222 |
| PubMed_21979375_A2 | Down | -0.4587525599 |
| GSE35957 | Up | 0.4828852894 |
| GSE36640 | Up | 0.2403642001 |
| GSE54402 | Down | -0.4808975024 |
| GSE9593 | Up | 0.4477723967 |
| GSE43922 | Down | -0.3911482452 |
| GSE24585 | Down | -0.0003198930 |
| GSE37065 | Down | -0.3355547657 |
| GSE28863_A1 | Up | 1.6229201734 |
| GSE28863_A2 | Up | 1.7946166693 |
| GSE28863_A3 | Up | 0.2623908333 |
| GSE28863_A4 | Down | -0.1895714074 |
| GSE48662 | Down | -0.2597678995 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-16-5p | MIMAT0000069 | MIRT001446 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-29c-3p | MIMAT0000681 | MIRT001923 | Luciferase reporter assay//Reporter assay;Other | Functional MTI | 18390668 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT002720 | Microarray//qRT-PCR | Functional MTI (Weak) | 16549876 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT002720 | Microarray | Functional MTI (Weak) | 15685193 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT002720 | Immunoblot//Immunohistochemistry//qRT-PCR//Western blot | Functional MTI | 21196113 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT002720 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-205-5p | MIMAT0000266 | MIRT007075 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 22578566 |
| hsa-miR-98-5p | MIMAT0000096 | MIRT027555 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-10b-5p | MIMAT0000254 | MIRT047473 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-10a-5p | MIMAT0000253 | MIRT047628 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049658 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-29c-3p | MIMAT0000681 | NA | hsa-miR-29c | 18390668 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25087724 | Among them, miR-199b-5p directly suppressed LAMC1 expression, as shown in a luciferase assay |
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