HCSGD entry for LCT

1. General information

Official gene symbolLCT
Entrez ID3938
Gene full namelactase
Other gene symbolsLAC LPH LPH1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000016Lactase activityTASmolecular_function
GO:0004553Hydrolase activity, hydrolyzing O-glycosyl compoundsIEAmolecular_function
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0005975Carbohydrate metabolic processIEA TASbiological_process
GO:0016020MembraneTAScellular_component
GO:0016324Apical plasma membraneIEAcellular_component
GO:0017042Glycosylceramidase activityIEAmolecular_function
GO:0044245Polysaccharide digestionTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.61389938830.78597446150.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0386956290
GSE13712_SHEARUp0.0325355618
GSE13712_STATICUp0.0448744513
GSE19018Down-0.2586793829
GSE19899_A1Up0.0335927139
GSE19899_A2Up0.2514762276
PubMed_21979375_A1Up0.2465627324
PubMed_21979375_A2Down-0.0203545888
GSE35957Up0.0258863267
GSE36640Down-0.1183524595
GSE54402Up0.0976935760
GSE9593Up0.0794659691
GSE43922Up0.0153730305
GSE24585Down-0.1651844566
GSE37065Down-0.0347347099
GSE28863_A1Up0.0244238632
GSE28863_A2Up0.1386615098
GSE28863_A3Up0.1505850373
GSE28863_A4Up0.1239561036
GSE48662Down-0.0228046664

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Vitamin CDB00126 NUTR00001 | APRD00084 | EXPT00568 | DB09541
D-Gluconhydroximo-1,5-LactamDB02376 EXPT01630
Nojirimycine TetrazoleDB02471 EXPT02395
alpha-D-XylopyranoseDB03389 EXPT03270
2-deoxy-2-fluoro-??-D-glucoseDB04282 EXPT01525
GluconolactoneDB04564 EXPT02023
(1S,2S,3R,4S,5S)-2,3,4-TRIHYDROXY-5-(HYDROXYMETHYL)CYCLOHEXYL (1E)-2-PHENYL-N-(SULFOOXY)ETHANIMIDOTHIOATEDB04659 -
ETHYL (1E)-2-PHENYL-N-(SULFOOXY)ETHANIMIDOTHIOATEDB04779 -
2-HYDROXYMETHYL-6-OCTYLSULFANYL-TETRAHYDRO-PYRAN-3,4,5-TRIOLDB08558 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-671-5pMIMAT0003880MIRT039283CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.