HCSGD entry for LIG4

1. General information

Official gene symbolLIG4
Entrez ID3981
Gene full nameligase IV, DNA, ATP-dependent
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000012Single strand break repairIDAbiological_process
GO:0000793Condensed chromosomeIDAcellular_component
GO:0001701In utero embryonic developmentISSbiological_process
GO:0002328Pro-B cell differentiationISSbiological_process
GO:0003677DNA bindingIDAmolecular_function
GO:0003909DNA ligase activityIDA TASmolecular_function
GO:0003910DNA ligase (ATP) activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0005925Focal adhesionIDAcellular_component
GO:0005958DNA-dependent protein kinase-DNA ligase 4 complexIDA ISScellular_component
GO:0006266DNA ligationIDAbiological_process
GO:0006273Lagging strand elongationIBAbiological_process
GO:0006281DNA repairTASbiological_process
GO:0006297Nucleotide-excision repair, DNA gap fillingIDAbiological_process
GO:0006302Double-strand break repairIDA ISS TASbiological_process
GO:0006303Double-strand break repair via nonhomologous end joiningIDA IMP TASbiological_process
GO:0007049Cell cycleIEAbiological_process
GO:0007417Central nervous system developmentISSbiological_process
GO:0008022Protein C-terminus bindingIPImolecular_function
GO:0008283Cell proliferationISSbiological_process
GO:0010165Response to X-rayIMPbiological_process
GO:0010332Response to gamma radiationISSbiological_process
GO:0016032Viral processTASbiological_process
GO:0016874Ligase activityIDAmolecular_function
GO:0032807DNA ligase IV complexIMPcellular_component
GO:0033077T cell differentiation in thymusISSbiological_process
GO:0033151V(D)J recombinationIDAbiological_process
GO:0033152Immunoglobulin V(D)J recombinationIEAbiological_process
GO:0033153T cell receptor V(D)J recombinationISSbiological_process
GO:0035019Somatic stem cell maintenanceISSbiological_process
GO:0043524Negative regulation of neuron apoptotic processISSbiological_process
GO:0045190Isotype switchingISSbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048146Positive regulation of fibroblast proliferationISSbiological_process
GO:0050769Positive regulation of neurogenesisISSbiological_process
GO:0051102DNA ligation involved in DNA recombinationISSbiological_process
GO:0051103DNA ligation involved in DNA repairIDA ISSbiological_process
GO:0051276Chromosome organizationISSbiological_process
GO:0051301Cell divisionIEAbiological_process
GO:0051402Neuron apoptotic processISSbiological_process
GO:0070419Nonhomologous end joining complexIDAcellular_component
GO:0071285Cellular response to lithium ionIEAbiological_process
GO:0075713Establishment of integrated proviral latencyTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00580610540.98438497400.19924706651.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1165480564
GSE13712_SHEARUp0.2801264432
GSE13712_STATICUp0.5520063671
GSE19018Down-0.1082871679
GSE19899_A1Up0.9802940725
GSE19899_A2Up0.5489054130
PubMed_21979375_A1Up1.5208114116
PubMed_21979375_A2Up0.8919951256
GSE35957Up0.2867407358
GSE36640Up0.9736171940
GSE54402Up0.5993869446
GSE9593Down-0.2976258556
GSE43922Up0.6056141860
GSE24585Up0.2341326041
GSE37065Up0.0424326438
GSE28863_A1Up0.1618002428
GSE28863_A2Up0.1336241776
GSE28863_A3Up0.0311353323
GSE28863_A4Up0.1273068127
GSE48662Down-0.1708408621

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-132-3pMIMAT0000426MIRT021742MicroarrayFunctional MTI (Weak)17612493
hsa-miR-26b-5pMIMAT0000083MIRT028768MicroarrayFunctional MTI (Weak)19088304
hsa-miR-16-5pMIMAT0000069MIRT051082CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25921542Accordingly, LPC provoked oxidative DNA injury, whereas the gene expressions of DNA repair enzyme (OGG1, MUTYH, MTH1) remained unchanged
25582120Mechanistically, telomere fusions require either the classical non-homologous end-joining (C-NHEJ) pathway dependent on Ku70/80 and LIG4, or the alternative non-homologous end-joining (A-NHEJ), which relies on PARP1 and LIG3
24814484In particular, isw2Delta cells show an increased response to genotoxic stresses, and the DNA repair enzyme Rad51 is important for isw2Delta-mediated longevity
23542362SIRT1 is regulated by a NAD(+)-dependent DNA repair enzyme, poly(ADP-ribose) polymerase-1 (PARP1), and subsequent NAD(+) depletion by oxidative stress may have consequent effects on inflammatory and stress responses as well as cellular senescence
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