HCSGD entry for LNPEP
1. General information
| Official gene symbol | LNPEP |
|---|---|
| Entrez ID | 4012 |
| Gene full name | leucyl/cystinyl aminopeptidase |
| Other gene symbols | CAP IRAP P-LAP PLAP |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000209 | Protein polyubiquitination | TAS | biological_process |
| GO:0002474 | Antigen processing and presentation of peptide antigen via MHC class I | TAS | biological_process |
| GO:0002480 | Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent | TAS | biological_process |
| GO:0004177 | Aminopeptidase activity | EXP TAS | molecular_function |
| GO:0005576 | Extracellular region | IEA | cellular_component |
| GO:0005622 | Intracellular | IDA | cellular_component |
| GO:0005765 | Lysosomal membrane | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | TAS | cellular_component |
| GO:0006508 | Proteolysis | IEA | biological_process |
| GO:0007267 | Cell-cell signaling | TAS | biological_process |
| GO:0007565 | Female pregnancy | TAS | biological_process |
| GO:0008237 | Metallopeptidase activity | IEA | molecular_function |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0030163 | Protein catabolic process | IEA | biological_process |
| GO:0030659 | Cytoplasmic vesicle membrane | TAS | cellular_component |
| GO:0031905 | Early endosome lumen | TAS | cellular_component |
| GO:0042590 | Antigen processing and presentation of exogenous peptide antigen via MHC class I | TAS | biological_process |
| GO:0048471 | Perinuclear region of cytoplasm | IEA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0056163900 | 0.9891642871 | 0.1971814667 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1320422682 |
| GSE13712_SHEAR | Up | 0.6612540303 |
| GSE13712_STATIC | Up | 0.4638019614 |
| GSE19018 | Up | 0.2688306485 |
| GSE19899_A1 | Up | 0.4973036485 |
| GSE19899_A2 | Up | 1.2505770879 |
| PubMed_21979375_A1 | Up | 1.2439849165 |
| PubMed_21979375_A2 | Up | 1.1038499958 |
| GSE35957 | Up | 0.2019884476 |
| GSE36640 | Up | 0.7556218073 |
| GSE54402 | Up | 0.0741625258 |
| GSE9593 | Down | -0.0884706495 |
| GSE43922 | Up | 0.5275257620 |
| GSE24585 | Up | 0.4772593174 |
| GSE37065 | Up | 0.3527351724 |
| GSE28863_A1 | Up | 0.1059675856 |
| GSE28863_A2 | Up | 0.2459253452 |
| GSE28863_A3 | Down | -0.4996708189 |
| GSE28863_A4 | Down | -0.0921453490 |
| GSE48662 | Up | 0.2579392168 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT023791 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-877-5p | MIMAT0004949 | MIRT037306 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-744-5p | MIMAT0004945 | MIRT037514 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-18a-3p | MIMAT0002891 | MIRT040837 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-361-5p | MIMAT0000703 | MIRT044081 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-30e-3p | MIMAT0000693 | MIRT044123 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
