HCSGD entry for MEOX2
1. General information
| Official gene symbol | MEOX2 |
|---|---|
| Entrez ID | 4223 |
| Gene full name | mesenchyme homeobox 2 |
| Other gene symbols | GAX MOX2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001525 | Angiogenesis | IEA | biological_process |
| GO:0001757 | Somite specification | IEA | biological_process |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0007275 | Multicellular organismal development | TAS | biological_process |
| GO:0007519 | Skeletal muscle tissue development | IEA | biological_process |
| GO:0008015 | Blood circulation | TAS | biological_process |
| GO:0016607 | Nuclear speck | IEA | cellular_component |
| GO:0043565 | Sequence-specific DNA binding | IDA | molecular_function |
| GO:0060021 | Palate development | IEA | biological_process |
| GO:0060173 | Limb development | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2555338855 | 0.0821967516 | 0.9477113428 | 0.5429283061 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0353505831 |
| GSE13712_SHEAR | Down | -0.8922758980 |
| GSE13712_STATIC | Down | -0.9404140569 |
| GSE19018 | Up | 0.0109534504 |
| GSE19899_A1 | Up | 0.0579726618 |
| GSE19899_A2 | Down | -0.1678891408 |
| PubMed_21979375_A1 | Up | 0.1529992587 |
| PubMed_21979375_A2 | Up | 0.1768464472 |
| GSE35957 | Down | -1.9523253393 |
| GSE36640 | Up | 0.0047320115 |
| GSE54402 | Up | 0.0611543526 |
| GSE9593 | Up | 0.2560907249 |
| GSE43922 | Up | 0.0283751321 |
| GSE24585 | Up | 0.1717576497 |
| GSE37065 | Down | -0.9267607375 |
| GSE28863_A1 | Up | 0.0482691850 |
| GSE28863_A2 | Up | 0.6137878153 |
| GSE28863_A3 | Up | 0.5534728064 |
| GSE28863_A4 | Up | 0.0356947432 |
| GSE48662 | Down | -1.0199877768 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-301a-3p | MIMAT0000688 | MIRT003611 | Luciferase reporter assay | Functional MTI | 20470754 |
| hsa-miR-301a-3p | MIMAT0000688 | MIRT003611 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 22373864 |
| hsa-miR-130a-3p | MIMAT0000425 | MIRT004358 | Luciferase reporter assay//qRT-PCR//Western blot//Northern blot//Reporter assay;Other | Functional MTI | 17957028 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT018453 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT024208 | Western blot;qRT-PCR | Functional MTI | 20516212 |
| hsa-miR-320a | MIMAT0000510 | MIRT044481 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-130a-3p | MIMAT0000425 | NA | hsa-miR-130a | {Western blot} | {overexpression} | 17957028 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22206000 | Mechanisms of MEOX1 and MEOX2 regulation of the cyclin dependent kinase inhibitors p21 and p16 in vascular endothelial cells |
| 22206000 | The homeodomain transcription factor MEOX2 is an important regulator of vascular cell proliferation and is a direct transcriptional activator of both p21(CIP1/WAF1) and p16(INK4a) |
| 22206000 | MEOX1 and MEOX2 have been shown to be partially functionally redundant during development, suggesting that they regulate similar target genes in vivo |
| 22206000 | We compared the ability of MEOX1 and MEOX2 to activate p21(CIP1/WAF1) and p16(INK4a) expression and induce endothelial cell cycle arrest |
| 22206000 | Our results demonstrate for the first time that MEOX1 regulates the MEOX2 target genes p21(CIP1/WAF1) and p16(INK4a) |
| 22206000 | Furthermore, we show that the mechanism of transcriptional activation of these cyclin dependent kinase inhibitor genes by MEOX1 and MEOX2 is distinct |
| 22206000 | MEOX1 and MEOX2 activate p16(INK4a) in a DNA binding dependent manner, whereas they induce p21(CIP1/WAF1) in a DNA binding independent manner |
| 19340300 | A functional screen for regulators of CKDN2A reveals MEOX2 as a transcriptional activator of INK4a |
| 19340300 | We found that the transcription of one of these, the homeodomain protein MEOX2 (GAX) is enhanced in primary cells during the induction of senescence, and forced expression of this protein results in the induction of premature senescence |
| 19340300 | We further demonstrate that MEOX2-induced senescence is dependent upon INK4a activity, and chromatin immunoprecipitation studies indicate that MEOX2 directly binds the INK4a promoter |
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