HCSGD entry for ASCL1

1. General information

Official gene symbolASCL1
Entrez ID429
Gene full nameachaete-scute complex homolog 1 (Drosophila)
Other gene symbolsASH1 HASH1 MASH1 bHLHa46
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000989Transcription factor binding transcription factor activityISSmolecular_function
GO:0001764Neuron migrationIEAbiological_process
GO:0003358Noradrenergic neuron developmentISSbiological_process
GO:0003359Noradrenergic neuron fate commitmentIMPbiological_process
GO:0003677DNA bindingISSmolecular_function
GO:0003690Double-stranded DNA bindingIEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0007219Notch signaling pathwayIDAbiological_process
GO:0007389Pattern specification processIEAbiological_process
GO:0007400Neuroblast fate determinationIEAbiological_process
GO:0007405Neuroblast proliferationIEAbiological_process
GO:0010226Response to lithium ionIEAbiological_process
GO:0010468Regulation of gene expressionISSbiological_process
GO:0014003Oligodendrocyte developmentIEAbiological_process
GO:0021527Spinal cord association neuron differentiationIEAbiological_process
GO:0021530Spinal cord oligodendrocyte cell fate specificationIEAbiological_process
GO:0021750Vestibular nucleus developmentIEAbiological_process
GO:0021879Forebrain neuron differentiationIEAbiological_process
GO:0021892Cerebral cortex GABAergic interneuron differentiationIEPbiological_process
GO:0021954Central nervous system neuron developmentIEAbiological_process
GO:0021987Cerebral cortex developmentIEAbiological_process
GO:0022008NeurogenesisIDAbiological_process
GO:0032526Response to retinoic acidIEPbiological_process
GO:0042803Protein homodimerization activityIEAmolecular_function
GO:0043025Neuronal cell bodyIEAcellular_component
GO:0043066Negative regulation of apoptotic processIMPbiological_process
GO:0043425BHLH transcription factor bindingIPImolecular_function
GO:0043525Positive regulation of neuron apoptotic processIEAbiological_process
GO:0043565Sequence-specific DNA bindingIEAmolecular_function
GO:0045665Negative regulation of neuron differentiationIDAbiological_process
GO:0045666Positive regulation of neuron differentiationISSbiological_process
GO:0045747Positive regulation of Notch signaling pathwayIEAbiological_process
GO:0045787Positive regulation of cell cycleIEAbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0048485Sympathetic nervous system developmentNASbiological_process
GO:0048665Neuron fate specificationIEAbiological_process
GO:0050769Positive regulation of neurogenesisIEAbiological_process
GO:0050883Musculoskeletal movement, spinal reflex actionIEAbiological_process
GO:0051593Response to folic acidIEAbiological_process
GO:0060163Subpallium neuron fate commitmentIEAbiological_process
GO:0060165Regulation of timing of subpallium neuron differentiationIEAbiological_process
GO:0060166Olfactory pit developmentIEAbiological_process
GO:0060487Lung epithelial cell differentiationNASbiological_process
GO:0061100Lung neuroendocrine cell differentiationIEAbiological_process
GO:0061102Stomach neuroendocrine cell differentiationIEAbiological_process
GO:0061103Carotid body glomus cell differentiationIEAbiological_process
GO:0061104Adrenal chromaffin cell differentiationIEAbiological_process
GO:0061549Sympathetic ganglion developmentISSbiological_process
GO:0070849Response to epidermal growth factorIEAbiological_process
GO:0070888E-box bindingIDAmolecular_function
GO:0071259Cellular response to magnetismIEAbiological_process
GO:2000179Positive regulation of neural precursor cell proliferationIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.43485288550.94237146760.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0630159625
GSE13712_SHEARDown-0.0010758166
GSE13712_STATICDown-0.1163251280
GSE19018Up0.0786207734
GSE19899_A1Up0.1130995793
GSE19899_A2Up0.0196995841
PubMed_21979375_A1Up0.1208291256
PubMed_21979375_A2Up0.0270461070
GSE35957Up0.1029020225
GSE36640Up0.0978848031
GSE54402Up0.0386791870
GSE9593Up0.0069330143
GSE43922Up0.1058857232
GSE24585Up0.2201703450
GSE37065Down-0.0396963071
GSE28863_A1Up0.1948412027
GSE28863_A2Down-0.1193286277
GSE28863_A3Up0.2386374197
GSE28863_A4Up0.1552703666
GSE48662Down-0.1431170316

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.