HCSGD entry for MLN
1. General information
| Official gene symbol | MLN |
|---|---|
| Entrez ID | 4295 |
| Gene full name | motilin |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005102 | Receptor binding | TAS | molecular_function |
| GO:0005179 | Hormone activity | IEA | molecular_function |
| GO:0005576 | Extracellular region | TAS | cellular_component |
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | biological_process |
| GO:0007267 | Cell-cell signaling | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1431474184 | 0.9728465864 | 0.7579527660 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1156903980 |
| GSE13712_SHEAR | Up | 0.0755189808 |
| GSE13712_STATIC | Up | 0.0339441068 |
| GSE19018 | Up | 0.2811223412 |
| GSE19899_A1 | Up | 0.1729460821 |
| GSE19899_A2 | Up | 0.3449539507 |
| PubMed_21979375_A1 | Up | 0.3507539798 |
| PubMed_21979375_A2 | Up | 0.2658971805 |
| GSE35957 | Up | 0.1419513460 |
| GSE36640 | Down | -0.0567438648 |
| GSE54402 | Up | 0.0640862206 |
| GSE9593 | Up | 0.1105157098 |
| GSE43922 | Up | 0.0872267813 |
| GSE24585 | Up | 0.0851193274 |
| GSE37065 | Up | 0.0328530068 |
| GSE28863_A1 | Up | 0.0635604503 |
| GSE28863_A2 | Up | 0.2121043260 |
| GSE28863_A3 | Up | 0.0118989953 |
| GSE28863_A4 | Up | 0.2500290250 |
| GSE48662 | Down | -0.0663117507 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018464 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 1303099 | Using flow cytometric analysis, we found significant age-associated increases in the percentages of Pgp-1+ cells in the MLN as compared with a slight, but not significant, increase in the spleen |
| 1303099 | There were significant age-related increases in the percentages of Lyt-2+ cells in the spleen with no change in the MLN |
| 1303099 | These results indicate elevated levels of Pgp-1+ memory senescent cells in the MLN and these age-related shifts or changes in T lymphocyte subsets with age could contribute to the conserved immune responsiveness of senescent mucosal T lymphocytes |
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