HCSGD entry for ND4
1. General information
| Official gene symbol | ND4 |
|---|---|
| Entrez ID | 4538 |
| Gene full name | NADH dehydrogenase, subunit 4 (complex I) |
| Other gene symbols | MTND4 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
Not in the Gene ontology4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1251912807 | 0.8447063827 | 0.7220893295 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2522599239 |
| GSE13712_SHEAR | Down | -0.1524461611 |
| GSE13712_STATIC | Down | -0.0511959990 |
| GSE19018 | Up | 0.3458832444 |
| GSE19899_A1 | Up | 0.1312441450 |
| GSE19899_A2 | Up | 0.8679061433 |
| PubMed_21979375_A1 | Up | 0.1514380734 |
| PubMed_21979375_A2 | Up | 0.4719508828 |
| GSE35957 | Up | 0.0675818419 |
| GSE36640 | Up | 0.3134564575 |
| GSE54402 | Down | -0.0023754305 |
| GSE9593 | Up | 0.0718036728 |
| GSE43922 | Up | 0.0883788029 |
| GSE24585 | Up | 0.0761394269 |
| GSE37065 | Down | -0.0366562488 |
| GSE28863_A1 | Down | -0.4627340182 |
| GSE28863_A2 | Down | -0.3130998968 |
| GSE28863_A3 | Up | 0.4808448599 |
| GSE28863_A4 | Down | -0.1682221563 |
| GSE48662 | - | - |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| NADH | DB00157 | NUTR00041 | DB01907 | EXPT02287 | DB03527 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-455-3p | MIMAT0004784 | MIRT037806 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-296-3p | MIMAT0004679 | MIRT038401 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-652-3p | MIMAT0003322 | MIRT039502 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044452 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-196a-5p | MIMAT0000226 | MIRT048266 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-17-5p | MIMAT0000070 | MIRT050806 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7f-5p | MIMAT0000067 | MIRT051369 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7e-5p | MIMAT0000066 | MIRT051479 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7c-5p | MIMAT0000064 | MIRT051789 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT051935 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 10362024 | We confirmed our previous report of a senescence-related increase in the abundance of ND4, a mitochondrially encoded subunit of NADH dehydrogenase |
| 7628554 | Sequence analysis revealed that these cDNA clones were homologous to the human mitochondrial genes for cytochrome b (cytb) and NADH dehydrogenase subunit 4/4L (ND4/4L) |
| 7628554 | However, the expression of the mitochondrial cytochrome oxidase I gene was similar between young and senescent cells, implying that the preferential expression of the mitochondrial genes in the senescent cells was selective for cytb and ND4/4L genes |
| 7628554 | The results suggest that expressions of mitochondrial cytb and ND4/4L genes are regulated by a senescence-dependent mechanism |
| 1279330 | Two of the genes with elevated RNA expression in the senescent cells are the mitochondria-coded genes for NADH dehydrogenase subunit 4 and for cytochrome b |
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