HCSGD entry for NBN

1. General information

Official gene symbolNBN
Entrez ID4683
Gene full namenibrin
Other gene symbolsAT-V1 AT-V2 ATV NBS NBS1 P95
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000077DNA damage checkpointIDAbiological_process
GO:0000723Telomere maintenanceIMPbiological_process
GO:0000724Double-strand break repair via homologous recombinationTASbiological_process
GO:0000784Nuclear chromosome, telomeric regionIDAcellular_component
GO:0001832Blastocyst growthIEAbiological_process
GO:0003684Damaged DNA bindingIC IEAmolecular_function
GO:0004003ATP-dependent DNA helicase activityIMPmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005657Replication forkIEAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0006200ATP catabolic processIMPbiological_process
GO:0006281DNA repairTASbiological_process
GO:0006302Double-strand break repairIDA TASbiological_process
GO:0007050Cell cycle arrestTASbiological_process
GO:0007093Mitotic cell cycle checkpointIDAbiological_process
GO:0007095Mitotic G2 DNA damage checkpointIDA IEAbiological_process
GO:0007126MeiosisIEAbiological_process
GO:0008134Transcription factor bindingIPImolecular_function
GO:0008283Cell proliferationIEAbiological_process
GO:0016605PML bodyIDAcellular_component
GO:0030174Regulation of DNA-dependent DNA replication initiationTASbiological_process
GO:0030330DNA damage response, signal transduction by p53 class mediatorTASbiological_process
GO:0030870Mre11 complexIDAcellular_component
GO:0031954Positive regulation of protein autophosphorylationIDAbiological_process
GO:0032508DNA duplex unwindingIMPbiological_process
GO:0033674Positive regulation of kinase activityIDAbiological_process
GO:0035861Site of double-strand breakIDAcellular_component
GO:0042405Nuclear inclusion bodyIDAcellular_component
GO:0045190Isotype switchingIEAbiological_process
GO:0047485Protein N-terminus bindingIPImolecular_function
GO:0050885Neuromuscular process controlling balanceIEAbiological_process
GO:0097193Intrinsic apoptotic signaling pathwayIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.15529366290.04719664150.78327639290.4079281024

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.5554019762
GSE13712_SHEARUp0.4585939077
GSE13712_STATICUp0.2524701558
GSE19018Down-0.3049886470
GSE19899_A1Up0.2963999044
GSE19899_A2Up0.2201989293
PubMed_21979375_A1Up0.2173414012
PubMed_21979375_A2Up0.4532796289
GSE35957Down-0.7807658756
GSE36640Down-0.4710134192
GSE54402Up0.4909274744
GSE9593Down-0.3745827681
GSE43922Up0.1779812560
GSE24585Down-1.2438053584
GSE37065Up0.1950577202
GSE28863_A1Down-0.0715487188
GSE28863_A2Down-0.2203078184
GSE28863_A3Down-1.1136542231
GSE28863_A4Up0.2428611709
GSE48662Down-0.6636546939

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-132-3pMIMAT0000426MIRT021833MicroarrayFunctional MTI (Weak)17612493
hsa-miR-215-5pMIMAT0000272MIRT024642MicroarrayFunctional MTI (Weak)19074876
hsa-miR-192-5pMIMAT0000222MIRT026789MicroarrayFunctional MTI (Weak)19074876
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26731175We determined associations of frailty phenotype, a T-cell senescence marker (p16(INK4a) expression), age and demographics with exposures of the intracellular metabolites (IM) and endogenous nucleotides (EN) of tenofovir/emtricitabine (TFV/FTC), efavirenz (EFV), atazanavir (ATV) and ritonavir (RTV)
26731175METHODS: Plasma and peripheral blood mononuclear cell samples for drug, IM and EN concentrations were collected at four time points in HIV+ adults receiving TFV/FTC with EFV or ATV/RTV
26731175No associations were observed for EFV, ATV or RTV AUCs
259488639% in the ATV/r group vs -3
25119968The role of nibrin in doxorubicin-induced apoptosis and cell senescence in Nijmegen Breakage Syndrome patients lymphocytes
25119968Nibrin plays an important role in the DNA damage response (DDR) and DNA repair
25119968To verify whether truncated nibrin (p70), causing Nijmegen Breakage Syndrome (NBS), is involved in DDR and cell fate upon DNA damage, we used two (S4 and S3R) spontaneously immortalized T cell lines from NBS patients, with the founding mutation and a control cell line (L5)
25119968S4 and S3R cells have the same level of p70 nibrin, however p70 from S4 cells was able to form more complexes with ATM and BRCA1
25119968Downregulation of nibrin in normal human vascular smooth muscle cells (VSMCs) did not prevent the activation of DDR and induction of senescence
25119968Our results indicate that a substantially reduced level of nibrin or its truncated p70 form is sufficient to induce DNA-damage dependent senescence in VSMCs and S4 cells, respectively
19442255It is known that telomere length maintenance in ALT+ cells is dependent on the MRN [MRE11 (meiotic recombination 11)-Rad50-NBS1 (Nijmegen breakage syndrome 1)] complex, but knowledge of the role of other genes, including the Werner's (WRN) and Bloom's (BLM) syndrome DNA helicase genes, is still limited
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