HCSGD entry for ATIC

1. General information

Official gene symbolATIC
Entrez ID471
Gene full name5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
Other gene symbolsAICAR AICARFT IMPCHASE PURH
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003360Brainstem developmentIEAbiological_process
GO:0003937IMP cyclohydrolase activityIEA TASmolecular_function
GO:0004643Phosphoribosylaminoimidazolecarboxamide formyltransferase activityIEA TASmolecular_function
GO:0005739MitochondrionIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006139Nucleobase-containing compound metabolic processTASbiological_process
GO:0006144Purine nucleobase metabolic processTASbiological_process
GO:0006164Purine nucleotide biosynthetic processIEAbiological_process
GO:0006189'de novo' IMP biosynthetic processIEAbiological_process
GO:0009116Nucleoside metabolic processIEAbiological_process
GO:0009168Purine ribonucleoside monophosphate biosynthetic processTASbiological_process
GO:0009259Ribonucleotide metabolic processIEAbiological_process
GO:0010035Response to inorganic substanceIEAbiological_process
GO:0021549Cerebellum developmentIEAbiological_process
GO:0021987Cerebral cortex developmentIEAbiological_process
GO:0031100Organ regenerationIEAbiological_process
GO:0042803Protein homodimerization activityIPImolecular_function
GO:0044281Small molecule metabolic processTASbiological_process
GO:0046452Dihydrofolate metabolic processIEAbiological_process
GO:0046654Tetrahydrofolate biosynthetic processIEAbiological_process
GO:0055086Nucleobase-containing small molecule metabolic processTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.46706320430.19584174610.99999024730.8573830534

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.3068767690
GSE13712_SHEARUp0.1119127503
GSE13712_STATICUp0.2836159992
GSE19018Down-0.6428139615
GSE19899_A1Up0.1721481186
GSE19899_A2Up0.0013562869
PubMed_21979375_A1Up0.1755871048
PubMed_21979375_A2Up0.1964236368
GSE35957Down-0.4317173437
GSE36640Down-0.6947113822
GSE54402Up0.4361608925
GSE9593Down-0.2231936776
GSE43922Up0.1713957645
GSE24585Down-0.5150134073
GSE37065Down-0.0659253927
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Down-0.3076841763

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Tetrahydrofolic acidDB00116 NUTR00056
PemetrexedDB00642 APRD00573 | EXPT02075
AicarDB01700 EXPT00407
Guanosine-5'-MonophosphateDB01972 EXPT00246
5--Monophosphate-9-Beta-D-Ribofuranosyl XanthineDB02309 EXPT03260
2-[5-Hydroxy-3-Methyl-1-(2-Methyl-4-Sulfo-Phenyl)-1h-Pyrazol-4-Ylazo]-4-Sulfo-Benzoic AcidDB03442 EXPT00150
Beta-Dadf, Msa, Multisubstrate Adduct InhibitorDB04057 EXPT02233

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-1180-3pMIMAT0005825MIRT035935CLASHFunctional MTI (Weak)23622248
hsa-miR-93-3pMIMAT0004509MIRT038893CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26386875We identified that the anti-senescence activity of MB (transient activator) was 8-times higher than that of AICAR (chronic activator)
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