HCSGD entry for ATOX1
1. General information
| Official gene symbol | ATOX1 |
|---|---|
| Entrez ID | 475 |
| Gene full name | antioxidant 1 copper chaperone |
| Other gene symbols | ATX1 HAH1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005507 | Copper ion binding | IDA IEA | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006825 | Copper ion transport | IEA TAS | biological_process |
| GO:0006878 | Cellular copper ion homeostasis | IEA | biological_process |
| GO:0006979 | Response to oxidative stress | IEA | biological_process |
| GO:0016530 | Metallochaperone activity | TAS | molecular_function |
| GO:0016531 | Copper chaperone activity | IDA | molecular_function |
| GO:0030001 | Metal ion transport | IEA | biological_process |
| GO:0032767 | Copper-dependent protein binding | IPI | molecular_function |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0138984499 | 0.9353179856 | 0.2937043965 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.9507621721 |
| GSE13712_SHEAR | Down | -0.1136938151 |
| GSE13712_STATIC | Up | 0.1020501116 |
| GSE19018 | Up | 0.5280367148 |
| GSE19899_A1 | Up | 0.2356328017 |
| GSE19899_A2 | Up | 0.5747082371 |
| PubMed_21979375_A1 | Up | 1.8381283195 |
| PubMed_21979375_A2 | Up | 0.3013511498 |
| GSE35957 | Down | -0.0075311324 |
| GSE36640 | Up | 0.5827240316 |
| GSE54402 | Up | 0.6226118618 |
| GSE9593 | Up | 0.4063926757 |
| GSE43922 | Up | 0.1963771871 |
| GSE24585 | Down | -0.1881873959 |
| GSE37065 | Up | 0.3855416892 |
| GSE28863_A1 | Down | -0.3823966608 |
| GSE28863_A2 | Down | -0.2248656010 |
| GSE28863_A3 | Down | -0.3528262656 |
| GSE28863_A4 | Down | -0.0691288619 |
| GSE48662 | Up | 0.2359648689 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-30a-5p | MIMAT0000087 | MIRT028597 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031845 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT051900 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23274001 | 77 (nmol/min/mg protein) and upregulated the gene expression levels of copper transport protein ATOX1, glutathione synthetase (GSS) and thioredoxin reductase 1 (TXNRD1) while down-regulated aldehyde oxidase 1 (AOX1) |
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