HCSGD entry for NFATC1

1. General information

Official gene symbolNFATC1
Entrez ID4772
Gene full namenuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
Other gene symbolsNF-ATC NFAT2 NFATc
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000082G1/S transition of mitotic cell cycleIEAbiological_process
GO:0000790Nuclear chromatinIDAcellular_component
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA bindingISSmolecular_function
GO:0001085RNA polymerase II transcription factor bindingISSmolecular_function
GO:0001205RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionISSmolecular_function
GO:0001837Epithelial to mesenchymal transitionIEAbiological_process
GO:0003700Sequence-specific DNA binding transcription factor activityIEA TASmolecular_function
GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityISSmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005528FK506 bindingTASmolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005667Transcription factor complexIEAcellular_component
GO:0005737CytoplasmIEA ISScellular_component
GO:0005829CytosolTAScellular_component
GO:0006366Transcription from RNA polymerase II promoterTASbiological_process
GO:0006816Calcium ion transportIEAbiological_process
GO:0007507Heart developmentIEAbiological_process
GO:0030316Osteoclast differentiationIEAbiological_process
GO:0035556Intracellular signal transductionIDAbiological_process
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0043565Sequence-specific DNA bindingIEAmolecular_function
GO:0044212Transcription regulatory region DNA bindingIDAmolecular_function
GO:0045087Innate immune responseTASbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEA ISSbiological_process
GO:0048273Mitogen-activated protein kinase p38 bindingISSmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.70025157100.30966359560.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.2452956886
GSE13712_SHEARDown-0.6583635949
GSE13712_STATICDown-0.5700994267
GSE19018Up0.0504829611
GSE19899_A1Down-0.0431267811
GSE19899_A2Up0.0136194960
PubMed_21979375_A1Up0.1226644002
PubMed_21979375_A2Down-0.0001489200
GSE35957Down-0.3396930945
GSE36640Down-0.1337696018
GSE54402Up0.1068602755
GSE9593Up0.0905648786
GSE43922Down-0.1656971685
GSE24585Up0.3613592201
GSE37065Up0.1237523728
GSE28863_A1Down-0.0458566132
GSE28863_A2Up0.0446920964
GSE28863_A3Up0.4063421874
GSE28863_A4Up0.1001815685
GSE48662Down-0.0134456742

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-124-3pMIMAT0000422MIRT002918MicroarrayFunctional MTI (Weak)18668037
hsa-let-7b-5pMIMAT0000063MIRT052157CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26477312NFATc1 promotes prostate tumorigenesis and overcomes PTEN loss-induced senescence
26477312We found the upregulation of nuclear factor of activated T cells c1 (NFATc1) in human PCa and cultured PCa cells, but not in normal prostates and non-tumorigenic prostate cells
26477312To understand the role of NFATc1 in prostate tumorigenesis in situ, we temporally and spatially controlled the activation of NFATc1 in mouse prostate and showed that such activation resulted in prostatic adenocarcinoma with features similar to those seen in human PCa
26477312Our results indicate that the activation of a single transcription factor, NFATc1 in prostatic luminal epithelium to PCa can affect expression of diverse factors in both cells harboring the genetic changes and in neighboring cells through microenvironmental alterations
26477312In addition to the activation of oncogenes c-MYC and STAT3 in tumor cells, a number of cytokines and growth factors, such as IL1beta, IL6 and SPP1 (osteopontin, a key biomarker for PCa), were upregulated in NFATc1-induced PCa, establishing a tumorigenic microenvironment involving both NFATc1 positive and negative cells for prostate tumorigenesis
26477312To further characterize interactions between genes involved in prostate tumorigenesis, we generated mice with both NFATc1 activation and Pten inactivation in prostate
26477312We showed that NFATc1 activation led to acceleration of Pten null-driven prostate tumorigenesis by overcoming the PTEN loss-induced cellular senescence through inhibition of p21 activation
26477312This study provides direct in vivo evidence of an oncogenic role of NFATc1 in prostate tumorigenesis and reveals multiple functions of NFATc1 in activating oncogenes, in inducing proinflammatory cytokines, in oncogene addiction, and in overcoming cellular senescence, which suggests calcineurin-NFAT signaling as a potential target in preventing PCa
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