HCSGD entry for NGFR

1. General information

Official gene symbolNGFR
Entrez ID4804
Gene full namenerve growth factor receptor
Other gene symbolsCD271 Gp80-LNGFR TNFRSF16 p75(NTR) p75NTR
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004871Signal transducer activityTASmolecular_function
GO:0004872Receptor activityTASmolecular_function
GO:0004888Transmembrane signaling receptor activityTASmolecular_function
GO:0005035Death receptor activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0005768EndosomeTAScellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneIEA TAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006886Intracellular protein transportISSbiological_process
GO:0007411Axon guidanceIEAbiological_process
GO:0007417Central nervous system developmentIEAbiological_process
GO:0008625Extrinsic apoptotic signaling pathway via death domain receptorsIEAbiological_process
GO:0009986Cell surfaceISScellular_component
GO:0010468Regulation of gene expressionIEAbiological_process
GO:0016048Detection of temperature stimulusIEAbiological_process
GO:0017137Rab GTPase bindingISSmolecular_function
GO:0021675Nerve developmentIEAbiological_process
GO:0031069Hair follicle morphogenesisIEAbiological_process
GO:0031293Membrane protein intracellular domain proteolysisTASbiological_process
GO:0031625Ubiquitin protein ligase bindingIPImolecular_function
GO:0040037Negative regulation of fibroblast growth factor receptor signaling pathwayIEAbiological_process
GO:0042488Positive regulation of odontogenesis of dentin-containing toothIEAbiological_process
GO:0042593Glucose homeostasisISSbiological_process
GO:0043065Positive regulation of apoptotic processTASbiological_process
GO:0043066Negative regulation of apoptotic processTASbiological_process
GO:0043281Regulation of cysteine-type endopeptidase activity involved in apoptotic processTASbiological_process
GO:0045786Negative regulation of cell cycleTASbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0048146Positive regulation of fibroblast proliferationIEAbiological_process
GO:0048406Nerve growth factor bindingIEAmolecular_function
GO:0050770Regulation of axonogenesisTASbiological_process
GO:0050771Negative regulation of axonogenesisTASbiological_process
GO:0050772Positive regulation of axonogenesisTASbiological_process
GO:0051799Negative regulation of hair follicle developmentIEAbiological_process
GO:0097190Apoptotic signaling pathwayTASbiological_process
GO:2001235Positive regulation of apoptotic signaling pathwayIEAbiological_process
GO:2001273Regulation of glucose import in response to insulin stimulusISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.30562902250.85006423010.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0550881620
GSE13712_SHEARUp0.0067178264
GSE13712_STATICDown-0.0568206964
GSE19018Up0.2048807174
GSE19899_A1Up0.0220971291
GSE19899_A2Up0.0540517147
PubMed_21979375_A1Up0.4216088873
PubMed_21979375_A2Down-0.0704199719
GSE35957Down-0.0570683107
GSE36640Up0.0650631570
GSE54402Up0.0154983600
GSE9593Down-0.1672803326
GSE43922Up0.0558672367
GSE24585Up0.2877446938
GSE37065Down-0.1274167971
GSE28863_A1Down-0.0084321077
GSE28863_A2Down-0.1682534759
GSE28863_A3Up0.3962322642
GSE28863_A4Up0.0839985132
GSE48662Up0.4101924216

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT016762MicroarrayFunctional MTI (Weak)18185580
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25879198Moreover, undifferentiated STRO-1(+)/c-Kit(+)/CD34(-) hDPSCs did not show any expression of CD271 and nestin, typical neural markers, while STRO-1(+)/c-Kit(+)/CD34(+) hDPSCs expressed both
25720390Basal and suprabasal keratinocyte phenotypes were determined by the expression levels of 14-3-3sigma, p75(NTR) and alpha6 integrin
25360110Thus, in the adult and aged distal parts of the colon a marked decrease in relative gene expression of neural key genes like NGFR, RET, NOS1 and a concurrent increase of CHAT were observed
12803109What is important, however, is the induction of cells that have an atypical to this pathway allure staining positive for the neurofilament 3A10 monoclonal antibody, specific for nerve cells and the anti-p75 (Nerve Growth Factor Receptor) monoclonal antibody
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