HCSGD entry for NRD1
1. General information
| Official gene symbol | NRD1 |
|---|---|
| Entrez ID | 4898 |
| Gene full name | nardilysin (N-arginine dibasic convertase) |
| Other gene symbols | hNRD1 hNRD2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003824 | Catalytic activity | IEA | molecular_function |
| GO:0004222 | Metalloendopeptidase activity | IEA NAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006508 | Proteolysis | IEA NAS | biological_process |
| GO:0007528 | Neuromuscular junction development | TAS | biological_process |
| GO:0008283 | Cell proliferation | TAS | biological_process |
| GO:0009986 | Cell surface | TAS | cellular_component |
| GO:0016477 | Cell migration | TAS | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0048408 | Epidermal growth factor binding | TAS | molecular_function |
| GO:0051044 | Positive regulation of membrane protein ectodomain proteolysis | IDA | biological_process |
| GO:0052548 | Regulation of endopeptidase activity | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1841009726 | 0.5402384750 | 0.8390860087 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0125264666 |
| GSE13712_SHEAR | Up | 0.0438872431 |
| GSE13712_STATIC | Up | 0.1291457819 |
| GSE19018 | Up | 0.5034375124 |
| GSE19899_A1 | Down | -0.0247130785 |
| GSE19899_A2 | Down | -0.3531700671 |
| PubMed_21979375_A1 | Down | -0.5581652676 |
| PubMed_21979375_A2 | Down | -0.2836135345 |
| GSE35957 | Down | -0.2610889963 |
| GSE36640 | Up | 0.6610245195 |
| GSE54402 | Down | -0.0462266099 |
| GSE9593 | Down | -0.4117999884 |
| GSE43922 | Up | 0.0210684149 |
| GSE24585 | Up | 0.1574166836 |
| GSE37065 | Up | 0.0109774990 |
| GSE28863_A1 | Up | 0.4633916912 |
| GSE28863_A2 | Up | 1.0223468910 |
| GSE28863_A3 | Up | 0.1223714746 |
| GSE28863_A4 | Down | -0.0857878063 |
| GSE48662 | Down | -0.0515249540 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029502 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040263 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-181d-5p | MIMAT0002821 | MIRT041161 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-125b-5p | MIMAT0000423 | MIRT046070 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-181b-5p | MIMAT0000257 | MIRT047224 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052237 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
