HCSGD entry for PAPPA
1. General information
| Official gene symbol | PAPPA |
|---|---|
| Entrez ID | 5069 |
| Gene full name | pregnancy-associated plasma protein A, pappalysin 1 |
| Other gene symbols | ASBABP2 DIPLA1 IGFBP-4ase PAPA PAPP-A PAPPA1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004175 | Endopeptidase activity | IEA | molecular_function |
| GO:0005576 | Extracellular region | IDA NAS TAS | cellular_component |
| GO:0005615 | Extracellular space | IEA | cellular_component |
| GO:0006508 | Proteolysis | IEA | biological_process |
| GO:0007565 | Female pregnancy | NAS | biological_process |
| GO:0008237 | Metallopeptidase activity | IDA NAS | molecular_function |
| GO:0008270 | Zinc ion binding | NAS | molecular_function |
| GO:0016020 | Membrane | IEA | cellular_component |
| GO:0030154 | Cell differentiation | IEA | biological_process |
| GO:0032354 | Response to follicle-stimulating hormone | IEA | biological_process |
| GO:0044267 | Cellular protein metabolic process | TAS | biological_process |
| GO:0051384 | Response to glucocorticoid | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0119536796 | 0.3696441055 | 0.2735937391 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.5324851388 |
| GSE13712_SHEAR | Down | -0.3525924312 |
| GSE13712_STATIC | Down | -0.0625444398 |
| GSE19018 | Up | 0.6113106799 |
| GSE19899_A1 | Up | 0.0032605424 |
| GSE19899_A2 | Down | -0.1209298304 |
| PubMed_21979375_A1 | Down | -1.1610373230 |
| PubMed_21979375_A2 | Up | 0.3044545695 |
| GSE35957 | Up | 0.8210916640 |
| GSE36640 | Up | 2.1527292337 |
| GSE54402 | Down | -0.1733194764 |
| GSE9593 | Up | 0.3217997638 |
| GSE43922 | Up | 0.1629318455 |
| GSE24585 | Down | -0.2286334608 |
| GSE37065 | Up | 0.3589673281 |
| GSE28863_A1 | Up | 0.2853233484 |
| GSE28863_A2 | Up | 0.0868124893 |
| GSE28863_A3 | Up | 0.7292621592 |
| GSE28863_A4 | Down | -0.3870809301 |
| GSE48662 | Up | 0.6288263692 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-7-5p | MIMAT0000252 | MIRT025857 | Microarray | Functional MTI (Weak) | 19073608 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029988 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
