HCSGD entry for YARS2
1. General information
| Official gene symbol | YARS2 |
|---|---|
| Entrez ID | 51067 |
| Gene full name | tyrosyl-tRNA synthetase 2, mitochondrial |
| Other gene symbols | MLASA2 MT-TYRRS TYRRS |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000049 | TRNA binding | IDA TAS | molecular_function |
| GO:0004831 | Tyrosine-tRNA ligase activity | IDA IEA NAS TAS | molecular_function |
| GO:0005524 | ATP binding | IEA TAS | molecular_function |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005739 | Mitochondrion | IC NAS TAS | cellular_component |
| GO:0005759 | Mitochondrial matrix | TAS | cellular_component |
| GO:0006412 | Translation | NAS | biological_process |
| GO:0006418 | TRNA aminoacylation for protein translation | TAS | biological_process |
| GO:0006437 | Tyrosyl-tRNA aminoacylation | IEA | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0042803 | Protein homodimerization activity | IPI | molecular_function |
| GO:0043039 | TRNA aminoacylation | IDA | biological_process |
| GO:0070184 | Mitochondrial tyrosyl-tRNA aminoacylation | IC IMP | biological_process |
| GO:0072545 | Tyrosine binding | IDA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1257302496 | 0.5926137951 | 0.7230382128 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0250695883 |
| GSE13712_SHEAR | Up | 0.1612783785 |
| GSE13712_STATIC | Up | 0.2361008258 |
| GSE19018 | Down | -0.3345658420 |
| GSE19899_A1 | Up | 0.3718288178 |
| GSE19899_A2 | Up | 0.6747074649 |
| PubMed_21979375_A1 | Up | 0.6299977932 |
| PubMed_21979375_A2 | Up | 0.5569928673 |
| GSE35957 | Down | -0.0790500068 |
| GSE36640 | Down | -0.3639425384 |
| GSE54402 | Up | 0.4312234103 |
| GSE9593 | Down | -0.2287096880 |
| GSE43922 | Up | 0.4378644584 |
| GSE24585 | Down | -0.5316949863 |
| GSE37065 | Up | 0.0456165925 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Down | -0.4281708927 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-16-5p | MIMAT0000069 | MIRT031764 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-149-5p | MIMAT0000450 | MIRT045500 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7f-5p | MIMAT0000067 | MIRT051361 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
