HCSGD entry for PDE3B

1. General information

Official gene symbolPDE3B
Entrez ID5140
Gene full namephosphodiesterase 3B, cGMP-inhibited
Other gene symbolsHcGIP1 cGIPDE1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001525AngiogenesisIEAbiological_process
GO:00041143',5'-cyclic-nucleotide phosphodiesterase activityIEA TASmolecular_function
GO:0004119CGMP-inhibited cyclic-nucleotide phosphodiesterase activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005783Endoplasmic reticulumISScellular_component
GO:0005794Golgi apparatusISScellular_component
GO:0005829CytosolTAScellular_component
GO:0006198CAMP catabolic processIEPbiological_process
GO:0007162Negative regulation of cell adhesionIMPbiological_process
GO:0007165Signal transductionIEAbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008286Insulin receptor signaling pathwayTASbiological_process
GO:0016020MembraneIDAcellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0016525Negative regulation of angiogenesisIMPbiological_process
GO:0031018Endocrine pancreas developmentIEAbiological_process
GO:0032045Guanyl-nucleotide exchange factor complexIDAcellular_component
GO:0032869Cellular response to insulin stimulusISSbiological_process
GO:0033629Negative regulation of cell adhesion mediated by integrinICbiological_process
GO:0042593Glucose homeostasisIEAbiological_process
GO:0043422Protein kinase B bindingISSmolecular_function
GO:0043951Negative regulation of cAMP-mediated signalingICbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0050796Regulation of insulin secretionIEAbiological_process
GO:0050995Negative regulation of lipid catabolic processIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.95538648990.06526791920.99999024730.4825609270

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0533806945
GSE13712_SHEARDown-0.1843568849
GSE13712_STATICDown-0.0498179980
GSE19018Down-0.1348066433
GSE19899_A1Down-0.0053677945
GSE19899_A2Down-0.6352180622
PubMed_21979375_A1Down-0.4477800866
PubMed_21979375_A2Down-0.2032459734
GSE35957Up0.1439044928
GSE36640Down-0.5174142079
GSE54402Down-0.4858624798
GSE9593Down-0.1487513954
GSE43922Up0.0132993638
GSE24585Down-0.6525271921
GSE37065Up0.6403879591
GSE28863_A1Up0.2381896802
GSE28863_A2Down-0.0920161421
GSE28863_A3Up0.0508446491
GSE28863_A4Down-0.1299402025
GSE48662Down-0.0358484794

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

(5r)-6-(4-{[2-(3-Iodobenzyl)-3-Oxocyclohex-1-En-1-Yl]Amino}Phenyl)-5-Methyl-4,5-Dihydropyridazin-3(2h)-OneDB01640 EXPT00272
Hg9a-9, Nonanoyl-N-HydroxyethylglucamideDB01970 EXPT01736
3-isobutyl-1-methyl-7H-xanthineDB07954 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-130b-3pMIMAT0000691MIRT020264SequencingFunctional MTI (Weak)20371350
hsa-miR-128-3pMIMAT0000424MIRT022058MicroarrayFunctional MTI (Weak)17612493
hsa-miR-124-3pMIMAT0000422MIRT022763MicroarrayFunctional MTI (Weak)18668037
hsa-miR-93-5pMIMAT0000093MIRT028148SequencingFunctional MTI (Weak)20371350
hsa-miR-16-5pMIMAT0000069MIRT051238CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.