HCSGD entry for PDE4D
1. General information
| Official gene symbol | PDE4D |
|---|---|
| Entrez ID | 5144 |
| Gene full name | phosphodiesterase 4D, cAMP-specific |
| Other gene symbols | ACRDYS2 DPDE3 HSPDE4D PDE43 PDE4DN2 STRK1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002027 | Regulation of heart rate | IEA ISS | biological_process |
| GO:0004114 | 3',5'-cyclic-nucleotide phosphodiesterase activity | IEA NAS | molecular_function |
| GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity | IDA IGI | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005815 | Microtubule organizing center | IEA | cellular_component |
| GO:0005829 | Cytosol | IDA TAS | cellular_component |
| GO:0005891 | Voltage-gated calcium channel complex | IEA ISS | cellular_component |
| GO:0006198 | CAMP catabolic process | IDA IEA IGI IMP | biological_process |
| GO:0006939 | Smooth muscle contraction | IEA | biological_process |
| GO:0007165 | Signal transduction | IEA | biological_process |
| GO:0007568 | Aging | IEA | biological_process |
| GO:0008144 | Drug binding | IPI | molecular_function |
| GO:0010469 | Regulation of receptor activity | ISS | biological_process |
| GO:0010880 | Regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum | IEA ISS | biological_process |
| GO:0016020 | Membrane | IDA | cellular_component |
| GO:0016324 | Apical plasma membrane | IEA | cellular_component |
| GO:0019899 | Enzyme binding | ISS | molecular_function |
| GO:0019933 | CAMP-mediated signaling | NAS | biological_process |
| GO:0030552 | CAMP binding | IDA | molecular_function |
| GO:0030593 | Neutrophil chemotaxis | IEA | biological_process |
| GO:0031625 | Ubiquitin protein ligase binding | IPI | molecular_function |
| GO:0031698 | Beta-2 adrenergic receptor binding | ISS | molecular_function |
| GO:0032729 | Positive regulation of interferon-gamma production | IMP | biological_process |
| GO:0032743 | Positive regulation of interleukin-2 production | IMP | biological_process |
| GO:0032754 | Positive regulation of interleukin-5 production | IMP | biological_process |
| GO:0033137 | Negative regulation of peptidyl-serine phosphorylation | IEA ISS | biological_process |
| GO:0034704 | Calcium channel complex | IDA | cellular_component |
| GO:0035264 | Multicellular organism growth | IEA | biological_process |
| GO:0044325 | Ion channel binding | IEA IPI ISS | molecular_function |
| GO:0045822 | Negative regulation of heart contraction | IEA ISS | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0050852 | T cell receptor signaling pathway | IMP | biological_process |
| GO:0051117 | ATPase binding | IEA IPI | molecular_function |
| GO:0060314 | Regulation of ryanodine-sensitive calcium-release channel activity | IEA ISS | biological_process |
| GO:0061028 | Establishment of endothelial barrier | ISS | biological_process |
| GO:0071222 | Cellular response to lipopolysaccharide | IEA | biological_process |
| GO:0071320 | Cellular response to cAMP | IDA | biological_process |
| GO:0071872 | Cellular response to epinephrine stimulus | IDA IEA | biological_process |
| GO:0071875 | Adrenergic receptor signaling pathway | ISS | biological_process |
| GO:0086004 | Regulation of cardiac muscle cell contraction | IEA ISS | biological_process |
| GO:0086024 | Adrenergic receptor signaling pathway involved in positive regulation of heart rate | IC | biological_process |
| GO:0097110 | Scaffold protein binding | IPI | molecular_function |
| GO:1901844 | Regulation of cell communication by electrical coupling involved in cardiac conduction | IC | biological_process |
| GO:1901898 | Negative regulation of relaxation of cardiac muscle | IEA ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1002698340 | 0.1614984651 | 0.6609561843 | 0.7758352072 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0891650471 |
| GSE13712_SHEAR | Up | 0.1629451444 |
| GSE13712_STATIC | Up | 0.6427083283 |
| GSE19018 | Up | 0.5072286024 |
| GSE19899_A1 | Up | 0.0685253250 |
| GSE19899_A2 | Down | -0.3723707784 |
| PubMed_21979375_A1 | Up | 1.6872420276 |
| PubMed_21979375_A2 | Up | 1.0024155959 |
| GSE35957 | Down | -0.7405656780 |
| GSE36640 | Down | -1.4822572736 |
| GSE54402 | Down | -0.9154376496 |
| GSE9593 | Down | -0.5454412001 |
| GSE43922 | Up | 0.7375117983 |
| GSE24585 | Down | -0.1452369309 |
| GSE37065 | Up | 0.3938322882 |
| GSE28863_A1 | Down | -0.1097594450 |
| GSE28863_A2 | Up | 0.0454177292 |
| GSE28863_A3 | Up | 0.0590707025 |
| GSE28863_A4 | Down | -0.0663745250 |
| GSE48662 | Up | 0.0263387687 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| Ketotifen | DB00920 | APRD01061 |
| Iloprost | DB01088 | APRD01027 |
| Roflumilast | DB01656 | EXPT02802 |
| Piclamilast | DB01791 | EXPT02600 |
| Rolipram | DB01954 | EXPT02804 |
| 3,5-Dimethyl-1-(3-Nitrophenyl)-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester | DB01959 | EXPT00309 |
| 2-[3-(2-Hydroxy-1,1-Dihydroxymethyl-Ethylamino)-Propylamino]-2-Hydroxymethyl-Propane-1,3-Diol | DB02676 | EXPT00612 |
| 6-(4-Difluoromethoxy-3-Methoxy-Phenyl)-2h-Pyridazin-3-One | DB02918 | EXPT03284 |
| 1-(4-Aminophenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester | DB03183 | EXPT00243 |
| (S)-Rolipram | DB03606 | EXPT00229 |
| Cilomilast | DB03849 | EXPT00920 |
| (R)-Rolipram | DB04149 | EXPT00228 |
| 3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester | DB04271 | EXPT01155 |
| 1-(4-Methoxyphenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester | DB04469 | EXPT00210 |
| AN2728 | DB05219 | - |
| OPC-6535 | DB05298 | - |
| Apremilast | DB05676 | - |
| (4R)-4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one | DB06842 | - |
| 3,5-DIMETHYL-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER | DB07051 | - |
| 3-isobutyl-1-methyl-7H-xanthine | DB07954 | - |
| 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid | DB08299 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018254 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-340-5p | MIMAT0004692 | MIRT019645 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-7-5p | MIMAT0000252 | MIRT025858 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-103a-3p | MIMAT0000101 | MIRT027087 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-19b-3p | MIMAT0000074 | MIRT031236 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-18a-5p | MIMAT0000072 | MIRT031356 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031849 | Sequencing | Functional MTI (Weak) | 20371350 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22684366 | The forced re-expression of AKAP12 in cancer cell lines suppresses in vitro parameters of oncogenic growth, invasiveness, and cell motility through its ability to scaffold protein kinase C (PKC), F-actin, cyclins, Src, and phosphoinositides, and possibly through additional scaffolding domains for PKA, calmodulin, beta1,4-galactosyltransferase-polypeptide-1, beta2-adrenergic receptors, and cAMP-specific 3',5'-cyclic phosphodiesterase 4D |
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