HCSGD entry for ZCCHC17
1. General information
| Official gene symbol | ZCCHC17 |
|---|---|
| Entrez ID | 51538 |
| Gene full name | zinc finger, CCHC domain containing 17 |
| Other gene symbols | HSPC251 PS1D RP11-266K22.1 pNO40 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005730 | Nucleolus | IEA | cellular_component |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0022625 | Cytosolic large ribosomal subunit | IEA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0248933741 | 0.9529566544 | 0.3720187181 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.4384331726 |
| GSE13712_SHEAR | Down | -0.1012407558 |
| GSE13712_STATIC | Up | 0.0642537058 |
| GSE19018 | Up | 0.5255585774 |
| GSE19899_A1 | Up | 0.5529728850 |
| GSE19899_A2 | Up | 0.5414932230 |
| PubMed_21979375_A1 | Up | 1.3237298516 |
| PubMed_21979375_A2 | Up | 0.4724478089 |
| GSE35957 | Down | -0.1829731982 |
| GSE36640 | Up | 0.1534093903 |
| GSE54402 | Up | 0.4471429672 |
| GSE9593 | Up | 0.0170752291 |
| GSE43922 | Up | 0.1132845603 |
| GSE24585 | Up | 0.1982266711 |
| GSE37065 | Up | 0.1972660258 |
| GSE28863_A1 | Down | -0.4159952994 |
| GSE28863_A2 | Down | -0.0385755619 |
| GSE28863_A3 | Down | -0.4447346383 |
| GSE28863_A4 | Down | -0.0242544334 |
| GSE48662 | Up | 0.2622742589 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26721440 | Target disruption of ribosomal protein pNO40 accelerates aging and impairs osteogenic differentiation of mesenchymal stem cells |
| 26721440 | Examination of the causal relationship between pNO40 deficiency and MSC-accelerated aging revealed big up tri, openE4 null disruption in MSCs elicits high levels of ROS and elevated expression levels of p16 and Rb but not p53 |
| 26721440 | Further analysis with iTraq identified CYP1B1, a component of the cytochrome p450 system, as a potential molecule mediating ROS generation in pNO40 deficient MSCs |
| 26721440 | We herein established a mouse model of MSC aging through pNO40-targeted depletion and demonstrated the effects of loss of pNO40 on bone homeostasis |
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