HCSGD entry for PDGFA

1. General information

Official gene symbolPDGFA
Entrez ID5154
Gene full nameplatelet-derived growth factor alpha polypeptide
Other gene symbolsPDGF-A PDGF1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000139Golgi membraneTAScellular_component
GO:0001525AngiogenesisISSbiological_process
GO:0001666Response to hypoxiaIEAbiological_process
GO:0001775Cell activationTASbiological_process
GO:0001942Hair follicle developmentISSbiological_process
GO:0002053Positive regulation of mesenchymal cell proliferationISSbiological_process
GO:0002576Platelet degranulationTASbiological_process
GO:0005161Platelet-derived growth factor receptor bindingIDA IPImolecular_function
GO:0005518Collagen bindingIDAmolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005615Extracellular spaceIDAcellular_component
GO:0005788Endoplasmic reticulum lumenTAScellular_component
GO:0005902MicrovillusISScellular_component
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007179Transforming growth factor beta receptor signaling pathwayIEAbiological_process
GO:0007267Cell-cell signalingTASbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008083Growth factor activityIDA IEAmolecular_function
GO:0008284Positive regulation of cell proliferationIDAbiological_process
GO:0008543Fibroblast growth factor receptor signaling pathwayTASbiological_process
GO:0009611Response to woundingIDAbiological_process
GO:0009790Embryo developmentTASbiological_process
GO:0009887Organ morphogenesisISSbiological_process
GO:0009986Cell surfaceIDAcellular_component
GO:0010035Response to inorganic substanceIEAbiological_process
GO:0010512Negative regulation of phosphatidylinositol biosynthetic processIDAbiological_process
GO:0010544Negative regulation of platelet activationIDAbiological_process
GO:0014068Positive regulation of phosphatidylinositol 3-kinase signalingIDAbiological_process
GO:0014910Regulation of smooth muscle cell migrationIDAbiological_process
GO:0016020MembraneIEAcellular_component
GO:0030031Cell projection assemblyISSbiological_process
GO:0030036Actin cytoskeleton organizationISSbiological_process
GO:0030168Platelet activationTASbiological_process
GO:0030198Extracellular matrix organizationTASbiological_process
GO:0030335Positive regulation of cell migrationIDAbiological_process
GO:0031093Platelet alpha granule lumenTAScellular_component
GO:0031954Positive regulation of protein autophosphorylationIDAbiological_process
GO:0032355Response to estradiolIEAbiological_process
GO:0032526Response to retinoic acidIEAbiological_process
GO:0032956Regulation of actin cytoskeleton organizationTASbiological_process
GO:0035793Positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathwayIDAbiological_process
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0042060Wound healingTASbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0042803Protein homodimerization activityIDAmolecular_function
GO:0043406Positive regulation of MAP kinase activityIDAbiological_process
GO:0043410Positive regulation of MAPK cascadeIMPbiological_process
GO:0043588Skin developmentISSbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045740Positive regulation of DNA replicationIDAbiological_process
GO:0046982Protein heterodimerization activityIPImolecular_function
GO:0048008Platelet-derived growth factor receptor signaling pathwayIDAbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0048015Phosphatidylinositol-mediated signalingTASbiological_process
GO:0048146Positive regulation of fibroblast proliferationIDAbiological_process
GO:0048286Lung alveolus developmentISSbiological_process
GO:0048407Platelet-derived growth factor bindingIPImolecular_function
GO:0048839Inner ear developmentIEAbiological_process
GO:0050730Regulation of peptidyl-tyrosine phosphorylationISSbiological_process
GO:0050919Negative chemotaxisIDAbiological_process
GO:0051781Positive regulation of cell divisionIEAbiological_process
GO:0051897Positive regulation of protein kinase B signalingIDAbiological_process
GO:0060683Regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signalingISSbiological_process
GO:0070374Positive regulation of ERK1 and ERK2 cascadeIDAbiological_process
GO:0072124Regulation of glomerular mesangial cell proliferationIDAbiological_process
GO:2000278Regulation of DNA biosynthetic processIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.98754651420.00687121310.99999024730.1653088342

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1230363931
GSE13712_SHEARUp0.0813244004
GSE13712_STATICDown-0.1937844427
GSE19018Down-0.3637356383
GSE19899_A1Down-0.3714410415
GSE19899_A2Down-0.5170903931
PubMed_21979375_A1Up0.0196905884
PubMed_21979375_A2Down-1.1755587137
GSE35957Down-0.7269310569
GSE36640Down-1.0588780502
GSE54402Down-0.0835210168
GSE9593Down-0.2953039457
GSE43922Down-0.2313637528
GSE24585Down-0.3761696608
GSE37065Down-0.3548339364
GSE28863_A1Down-0.2544924557
GSE28863_A2Down-0.0519103136
GSE28863_A3Down-0.0959566810
GSE28863_A4Down-0.3604953451
GSE48662Up0.6171235790

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-let-7d-5pMIMAT0000065MIRT005549ELISA//Immunoblot//Microarray//qRT-PCRFunctional MTI (Weak)21266476
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

19085240Proliferation, cell viability, mineralization assays, and mRNA levels were assessed for type I and III collagen, platelet-derived growth factor (PDGF)-1, basic fibroblast growth factor (bFGF), metalloproteinase (MMP)-2 and-8, and tissue inhibitor of metalloproteinases (TIMP)-1 and-2
19085240Gene expression analysis further showed that mRNA levels for bFGF, PDGF-1, and TIMP-2 were not affected by aging (p > 0
19054066Platination of telomeric sequences and nuclease hypersensitive elements of human c-myc and PDGF-A promoters and their ability to form G-quadruplexes
19054066The telomeric regions of DNA and nuclease hypersensitive elements of human c-myc and PDGF-A promoters represent a very appealing target for cisplatin and may interfere with normal DNA function
8106562We have previously found that stimulation of normal neonatal fibroblasts with PDGF or EGF leads to a transient induction of PDGF A-chain mRNA and the synthesis of PDGF-AA proteins
8106562We have now studied the PDGF-BB mediated PDGF A-chain induction in a set of fibroblasts from young and old donors to clarify if the levels of induction are correlated to the donor age and the replicative capacity of the cells
8106562The PDGF A-chain induction was found to be reduced in cells from old donors compared with cells from embryonic and neonatal donors
8106562The PDGF A-chain mRNA induction was also decreased or absent in late passage human fibroblasts (senescent cells) when compared with early passage cells
8106562These data suggest that the PDGF A-chain mRNA induction is regulated by an age related mechanism in human fibroblasts
2166059Although normal fibroblasts only express platelet-derived growth factor (PDGF) A-chain mRNA for a brief period following mitogenic stimulation, one strain of Hutchinson-Gilford (progeria) syndrome fibroblasts, AG3513, constitutively expresses PDGF A-chain mRNA and PDGF-AA homodimers
2166059The PDGF A-chain gene does not appear to be amplified or rearranged in these fibroblasts
2166059The senescent phenotype of AG3513 fibroblasts is probably unrelated to their constitutive PDGF A-chain gene expression; further studies are necessary in order to directly address this issue
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