HCSGD entry for PDGFRB
1. General information
| Official gene symbol | PDGFRB |
|---|---|
| Entrez ID | 5159 |
| Gene full name | platelet-derived growth factor receptor, beta polypeptide |
| Other gene symbols | CD140B IBGC4 JTK12 PDGFR PDGFR-1 PDGFR1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001701 | In utero embryonic development | IEA | biological_process |
| GO:0001894 | Tissue homeostasis | IEA | biological_process |
| GO:0004713 | Protein tyrosine kinase activity | IDA | molecular_function |
| GO:0004992 | Platelet activating factor receptor activity | TAS | molecular_function |
| GO:0005017 | Platelet-derived growth factor-activated receptor activity | TAS | molecular_function |
| GO:0005019 | Platelet-derived growth factor beta-receptor activity | IDA IEA IMP | molecular_function |
| GO:0005102 | Receptor binding | IPI | molecular_function |
| GO:0005161 | Platelet-derived growth factor receptor binding | IPI | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IEA ISS | cellular_component |
| GO:0005737 | Cytoplasm | IEA ISS | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0006024 | Glycosaminoglycan biosynthetic process | IEA | biological_process |
| GO:0007165 | Signal transduction | IDA | biological_process |
| GO:0007173 | Epidermal growth factor receptor signaling pathway | TAS | biological_process |
| GO:0007179 | Transforming growth factor beta receptor signaling pathway | IEA | biological_process |
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | biological_process |
| GO:0008284 | Positive regulation of cell proliferation | IEA IMP | biological_process |
| GO:0008543 | Fibroblast growth factor receptor signaling pathway | TAS | biological_process |
| GO:0009636 | Response to toxic substance | IEA | biological_process |
| GO:0010863 | Positive regulation of phospholipase C activity | IDA | biological_process |
| GO:0014068 | Positive regulation of phosphatidylinositol 3-kinase signaling | ISS | biological_process |
| GO:0014911 | Positive regulation of smooth muscle cell migration | IMP ISS | biological_process |
| GO:0016020 | Membrane | IDA | cellular_component |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0016023 | Cytoplasmic membrane-bounded vesicle | IEA | cellular_component |
| GO:0016324 | Apical plasma membrane | IEA ISS | cellular_component |
| GO:0016477 | Cell migration | IMP | biological_process |
| GO:0018108 | Peptidyl-tyrosine phosphorylation | IDA | biological_process |
| GO:0019901 | Protein kinase binding | IPI | molecular_function |
| GO:0030325 | Adrenal gland development | IEA | biological_process |
| GO:0030335 | Positive regulation of cell migration | IDA | biological_process |
| GO:0031226 | Intrinsic component of plasma membrane | IDA | cellular_component |
| GO:0032355 | Response to estradiol | IEA | biological_process |
| GO:0032516 | Positive regulation of phosphoprotein phosphatase activity | IDA | biological_process |
| GO:0032526 | Response to retinoic acid | IEA | biological_process |
| GO:0032956 | Regulation of actin cytoskeleton organization | ISS | biological_process |
| GO:0032967 | Positive regulation of collagen biosynthetic process | IEA | biological_process |
| GO:0034405 | Response to fluid shear stress | IEA | biological_process |
| GO:0035441 | Cell migration involved in vasculogenesis | ISS | biological_process |
| GO:0035789 | Metanephric mesenchymal cell migration | IEA | biological_process |
| GO:0035791 | Platelet-derived growth factor receptor-beta signaling pathway | IMP | biological_process |
| GO:0035793 | Positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway | ISS | biological_process |
| GO:0035909 | Aorta morphogenesis | ISS | biological_process |
| GO:0036120 | Cellular response to platelet-derived growth factor stimulus | IDA IMP | biological_process |
| GO:0038085 | Vascular endothelial growth factor binding | IPI | molecular_function |
| GO:0038091 | Positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway | IDA | biological_process |
| GO:0038095 | Fc-epsilon receptor signaling pathway | TAS | biological_process |
| GO:0042060 | Wound healing | IEA | biological_process |
| GO:0042542 | Response to hydrogen peroxide | IEA | biological_process |
| GO:0043066 | Negative regulation of apoptotic process | IEA | biological_process |
| GO:0043202 | Lysosomal lumen | IEA | cellular_component |
| GO:0043406 | Positive regulation of MAP kinase activity | ISS | biological_process |
| GO:0043548 | Phosphatidylinositol 3-kinase binding | IEA | molecular_function |
| GO:0043552 | Positive regulation of phosphatidylinositol 3-kinase activity | IDA | biological_process |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0045840 | Positive regulation of mitosis | ISS | biological_process |
| GO:0046488 | Phosphatidylinositol metabolic process | IMP | biological_process |
| GO:0046777 | Protein autophosphorylation | IDA | biological_process |
| GO:0048008 | Platelet-derived growth factor receptor signaling pathway | IDA | biological_process |
| GO:0048011 | Neurotrophin TRK receptor signaling pathway | TAS | biological_process |
| GO:0048015 | Phosphatidylinositol-mediated signaling | IMP TAS | biological_process |
| GO:0048407 | Platelet-derived growth factor binding | IDA IPI | molecular_function |
| GO:0048661 | Positive regulation of smooth muscle cell proliferation | IMP ISS | biological_process |
| GO:0048705 | Skeletal system morphogenesis | IEA | biological_process |
| GO:0048745 | Smooth muscle tissue development | IEA | biological_process |
| GO:0048839 | Inner ear development | IEA | biological_process |
| GO:0050730 | Regulation of peptidyl-tyrosine phosphorylation | IEA | biological_process |
| GO:0050921 | Positive regulation of chemotaxis | ISS | biological_process |
| GO:0055003 | Cardiac myofibril assembly | ISS | biological_process |
| GO:0055093 | Response to hyperoxia | IEA | biological_process |
| GO:0060326 | Cell chemotaxis | IDA | biological_process |
| GO:0060981 | Cell migration involved in coronary angiogenesis | ISS | biological_process |
| GO:0061298 | Retina vasculature development in camera-type eye | ISS | biological_process |
| GO:0070374 | Positive regulation of ERK1 and ERK2 cascade | IMP ISS | biological_process |
| GO:0071670 | Smooth muscle cell chemotaxis | ISS | biological_process |
| GO:0072075 | Metanephric mesenchyme development | IEA | biological_process |
| GO:0072262 | Metanephric glomerular mesangial cell proliferation involved in metanephros development | ISS | biological_process |
| GO:0072275 | Metanephric glomerulus morphogenesis | IEA | biological_process |
| GO:0072277 | Metanephric glomerular capillary formation | ISS | biological_process |
| GO:0072278 | Metanephric comma-shaped body morphogenesis | IEA | biological_process |
| GO:0072284 | Metanephric S-shaped body morphogenesis | IEA | biological_process |
| GO:0090280 | Positive regulation of calcium ion import | ISS | biological_process |
| GO:2000379 | Positive regulation of reactive oxygen species metabolic process | ISS | biological_process |
| GO:2000573 | Positive regulation of DNA biosynthetic process | ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5638683447 | 0.0016972531 | 0.9999902473 | 0.0791730973 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.9405473119 |
| GSE13712_SHEAR | Up | 0.2449112978 |
| GSE13712_STATIC | Up | 0.0716517184 |
| GSE19018 | Up | 0.4524389009 |
| GSE19899_A1 | Down | -0.9589751394 |
| GSE19899_A2 | Down | -3.6086538137 |
| PubMed_21979375_A1 | Down | -2.7584939401 |
| PubMed_21979375_A2 | Down | -2.1027892363 |
| GSE35957 | Down | -0.6281449617 |
| GSE36640 | Down | -0.2286514064 |
| GSE54402 | Down | -1.0473429178 |
| GSE9593 | Down | -0.0467877118 |
| GSE43922 | Down | -1.6602420627 |
| GSE24585 | Up | 0.1634587518 |
| GSE37065 | Down | -0.2351162493 |
| GSE28863_A1 | Up | 1.0151136342 |
| GSE28863_A2 | Up | 0.1692668600 |
| GSE28863_A3 | Down | -0.2364562515 |
| GSE28863_A4 | Down | -0.2316435303 |
| GSE48662 | Up | 0.5231808422 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| Becaplermin | DB00102 | BTD00053 | BIOD00053 |
| Sorafenib | DB00398 | APRD01304 | DB07438 |
| Imatinib | DB00619 | APRD01028 | EXPT02967 | DB03261 |
| Dasatinib | DB01254 | - |
| Sunitinib | DB01268 | DB07417 |
| XL999 | DB05014 | - |
| XL820 | DB05146 | - |
| Pazopanib | DB06589 | - |
| Regorafenib | DB08896 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-224-5p | MIMAT0000281 | MIRT000770 | Microarray//Northern blot | Functional MTI (Weak) | 16331254 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24471649 | These results suggest that the unresponsiveness of senescent fibroblasts to PDGF stimulation may be due to increased levels of PTRF and the formation of caveolae, which, in turn sequester growth receptors, such as PDGFR and its signalling molecules |
| 23591770 | Radiation-induced senescence in securin-deficient cancer cells promotes cell invasion involving the IL-6/STAT3 and PDGF-BB/PDGFR pathways |
| 23591770 | The IL-6/STAT3 signalling loop and platelet-derived growth factor-BB (PDGF-BB)/PDGF receptor (PDGFR) pathway were important for CM-induced cell migration and invasion |
| 16154800 | In the area of new drug development, a recurrent theme was receptor tyrosine kinase (TK) inhibitors, with multi-targeted, small molecule inhibitors - highly potent against a family of receptors such as vascular endothelial growth factor receptor (VEGFR), platelet-derived growth factor (PDGFR) and the receptor tyrosine kinase KIT - taking centre stage |
| 12086695 | The protein levels of PKC-alpha and PLC-gamma1 were unchanged, but those of PLD1 and PDGFR were reduced with age |
| 12086695 | The reduced content of PDGFR protein may be one of the important contributors to the failure of PDGF-stimulated signal transduction in human senescent fibroblasts |
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