HCSGD entry for MSRB1
1. General information
| Official gene symbol | MSRB1 |
|---|---|
| Entrez ID | 51734 |
| Gene full name | methionine sulfoxide reductase B1 |
| Other gene symbols | SELR SELX SEPX1 SepR |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003779 | Actin binding | ISS | molecular_function |
| GO:0005575 | Cellular_component | ND | cellular_component |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006979 | Response to oxidative stress | IEA | biological_process |
| GO:0008270 | Zinc ion binding | ISS | molecular_function |
| GO:0015629 | Actin cytoskeleton | ISS | cellular_component |
| GO:0030041 | Actin filament polymerization | ISS | biological_process |
| GO:0030091 | Protein repair | IEA ISS | biological_process |
| GO:0033743 | Peptide-methionine (R)-S-oxide reductase activity | IEA ISS | molecular_function |
| GO:0045087 | Innate immune response | ISS | biological_process |
| GO:0070191 | Methionine-R-sulfoxide reductase activity | IEA | molecular_function |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9943738688 | 0.0021779264 | 0.9999902473 | 0.0898514107 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.5269195197 |
| GSE13712_SHEAR | Down | -0.6562861855 |
| GSE13712_STATIC | Down | -0.2435732346 |
| GSE19018 | Down | -0.4427099616 |
| GSE19899_A1 | Down | -1.0867560883 |
| GSE19899_A2 | Down | -1.4667059344 |
| PubMed_21979375_A1 | Down | -1.1984958893 |
| PubMed_21979375_A2 | Down | -1.9455820587 |
| GSE35957 | Down | -0.5192860362 |
| GSE36640 | Down | -0.0860685366 |
| GSE54402 | Up | 0.2062166207 |
| GSE9593 | Down | -0.4005913612 |
| GSE43922 | Down | -0.6161564424 |
| GSE24585 | Up | 0.0085373989 |
| GSE37065 | Down | -0.1023221288 |
| GSE28863_A1 | Down | -0.4454576436 |
| GSE28863_A2 | Down | -0.4262742752 |
| GSE28863_A3 | Up | 0.0087334532 |
| GSE28863_A4 | Up | 0.2398175067 |
| GSE48662 | Down | -0.4731802143 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-149-5p | MIMAT0000450 | MIRT045669 | CLASH | Functional MTI (Weak) | 23622248 |
Entries Per Page
Displaying Page of
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 6 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23206970 | Genes encoding the enzyme methionine sulfoxide reductase type B, specific to the reduction of the oxidized methionine-R form, were characterized from the expressed (macronuclear) genome of two ecologically separate marine species of Euplotes, i |
| 22086179 | Methionine sulfoxide reductase A regulates cell growth through the p53-p21 pathway |
| 21784712 | Methionine sulfoxide reductase (Msr), a repair enzyme that reduces methionine sulfoxide residues in proteins damaged by oxidation, was also significantly upregulated (2 |
| 20102351 | Moreover, the oxidized protein repair system methionine sulfoxide reductase was more affected in the mitochondria than in the cytosol during cellular senescence |
| 15680234 | In a previous study, we reported that peptide methionine sulfoxide reductase activity as well as gene and protein expression of MsrA are decreased in various organs as a function of age |
| 12806056 | The proteasomal system is the major intracellular proteolytic pathway implicated in the degradation of oxidized protein, and the peptide methionine sulfoxide reductase catalyzes the reduction of methionine sulfoxide (i |
| 12806056 | Arguments for the implication of peptide methionine sulfoxide reductase in the age-related accumulation of oxidized protein are also discussed |
Entries Per Page
Displaying Page of
