HCSGD entry for CDK14
1. General information
| Official gene symbol | CDK14 |
|---|---|
| Entrez ID | 5218 |
| Gene full name | cyclin-dependent kinase 14 |
| Other gene symbols | PFTAIRE1 PFTK1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000086 | G2/M transition of mitotic cell cycle | IDA | biological_process |
| GO:0000308 | Cytoplasmic cyclin-dependent protein kinase holoenzyme complex | IDA | cellular_component |
| GO:0004672 | Protein kinase activity | IEA | molecular_function |
| GO:0004674 | Protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0004693 | Cyclin-dependent protein serine/threonine kinase activity | IMP | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | IEA | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0016055 | Wnt signaling pathway | IEA | biological_process |
| GO:0030332 | Cyclin binding | IPI | molecular_function |
| GO:0051301 | Cell division | IEA | biological_process |
| GO:0060828 | Regulation of canonical Wnt signaling pathway | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1319679343 | 0.4941154933 | 0.7370099724 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1148598688 |
| GSE13712_SHEAR | Down | -0.0591385033 |
| GSE13712_STATIC | Up | 0.2910636603 |
| GSE19018 | Down | -0.0176101970 |
| GSE19899_A1 | Up | 0.4735528379 |
| GSE19899_A2 | Up | 0.4575355788 |
| PubMed_21979375_A1 | Up | 0.3961811616 |
| PubMed_21979375_A2 | Up | 0.2120128302 |
| GSE35957 | Up | 0.1811065732 |
| GSE36640 | Down | -0.9942015879 |
| GSE54402 | Up | 0.8826844240 |
| GSE9593 | Down | -0.4375813568 |
| GSE43922 | Up | 0.3808079276 |
| GSE24585 | Down | -0.1668098218 |
| GSE37065 | Up | 0.0364326402 |
| GSE28863_A1 | Down | -0.0918861194 |
| GSE28863_A2 | Up | 0.4987235668 |
| GSE28863_A3 | Down | -0.2498200053 |
| GSE28863_A4 | Down | -0.2250831010 |
| GSE48662 | Down | -0.3330076323 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT003763 | Microarray | Functional MTI (Weak) | 15685193 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024450 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026414 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029296 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | NA | hsa-miR-1 | 15685193 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
